{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu X"],"funding":["Fight for Sight","Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust","Academy of Medical Sciences"],"pagination":["137-148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8935946"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(1)"],"pubmed_abstract":["<h4>Purpose</h4>This systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading.<h4>Methods</h4>Studies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted.<h4>Results</h4>Twelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies.<h4>Conclusion</h4>Retinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation."],"journal":["Ocular immunology and inflammation"],"pubmed_title":["Noninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review."],"pmcid":["PMC8935946"],"funding_grant_id":["24AZ171","MR/T019050/1","AMS-SGCL6-Keane","CL-2010-18-004","CS-2014-14-023","200141/Z/15/Z","1381","NIHR-RM-SR-2017-09-021-001"],"pubmed_authors":["Liu X","Keane PA","Way C","Adriano A","Moore DJ","Hui BT","Denniston AK","Beese S"],"additional_accession":[]},"is_claimable":false,"name":"Noninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review.","description":"<h4>Purpose</h4>This systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading.<h4>Methods</h4>Studies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted.<h4>Results</h4>Twelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies.<h4>Conclusion</h4>Retinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-05-30T15:17:06.853Z","creation":"2025-04-19T22:37:02.955Z"},"accession":"S-EPMC8935946","cross_references":{"pubmed":["33021418"],"doi":["10.1080/09273948.2020.1799038"]}}