biostudies-literatureLiu XFight for SightMedical Research CouncilNational Institute for Health Research (NIHR)Wellcome TrustAcademy of Medical Sciences137-148https://www.ebi.ac.uk/biostudies/studies/S-EPMC8935946biostudies-literatureUnknown30(1)<h4>Purpose</h4>This systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading.<h4>Methods</h4>Studies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted.<h4>Results</h4>Twelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies.<h4>Conclusion</h4>Retinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation.Ocular immunology and inflammationNoninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review.PMC893594624AZ171MR/T019050/1AMS-SGCL6-KeaneCL-2010-18-004CS-2014-14-023200141/Z/15/Z1381NIHR-RM-SR-2017-09-021-001Liu XKeane PAWay CAdriano AMoore DJHui BTDenniston AKBeese SfalseNoninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review.<h4>Purpose</h4>This systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading.<h4>Methods</h4>Studies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted.<h4>Results</h4>Twelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies.<h4>Conclusion</h4>Retinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation.2022-01-01T00:00:00Z2022 Jan2026-05-30T15:17:06.853Z2025-04-19T22:37:02.955ZS-EPMC89359463302141810.1080/09273948.2020.1799038