{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Bian-Fang Y"],"pubmed_abstract":["<h4>Objective</h4>This study is aimed at exploring the association between autophagy and tumor immune infiltration (TII) in colorectal cancer (CRC).<h4>Methods and materials</h4>We downloaded the transcriptome profiling and clinical data for CRC from The Cancer Genome Atlas (TCGA) database and obtained the normal colon transcriptome profiling data from Genotype-Tissue Expression Project (GTEx) database. The list of autophagy-related signatures was obtained from the Human Autophagy Database. We isolated the autophagy-related genes from the CRC gene expression matrix and constructed an autophagy-related prognostic (ARP) risk model. Then, we constructed a multiROC curve to validate the prognostic ability of the ARP risk model. CIBERSORT was used to determine the fractions of 22 immune cells i"],"journal":["Analytical cellular pathology (Amsterdam)"],"pagination":["2055676"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938087"],"repository":["biostudies-literature"],"pubmed_title":["The Role of Autophagy in Tumor Immune Infiltration in Colorectal Cancer."],"pmcid":["PMC8938087"],"pubmed_authors":["Qing-Feng W","Dong-Ning W","Yan Z","Ben-Jun W","Wen-Wen Z","Xin D","Jian-Yu S","Shi-Yi W","Bian-Fang Y","Dan T"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Autophagy in Tumor Immune Infiltration in Colorectal Cancer.","description":"<h4>Objective</h4>This study is aimed at exploring the association between autophagy and tumor immune infiltration (TII) in colorectal cancer (CRC).<h4>Methods and materials</h4>We downloaded the transcriptome profiling and clinical data for CRC from The Cancer Genome Atlas (TCGA) database and obtained the normal colon transcriptome profiling data from Genotype-Tissue Expression Project (GTEx) database. The list of autophagy-related signatures was obtained from the Human Autophagy Database. We isolated the autophagy-related genes from the CRC gene expression matrix and constructed an autophagy-related prognostic (ARP) risk model. Then, we constructed a multiROC curve to validate the prognostic ability of the ARP risk model. CIBERSORT was used to determine the fractions of 22 immune cells i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T04:42:06.182Z","creation":"2025-04-06T11:12:59.377Z"},"accession":"S-EPMC8938087","cross_references":{"pubmed":["35321516"],"doi":["10.1155/2022/2055676"]}}