biostudies-literatureUnknown2022Bian-Fang Y<h4>Objective</h4>This study is aimed at exploring the association between autophagy and tumor immune infiltration (TII) in colorectal cancer (CRC).<h4>Methods and materials</h4>We downloaded the transcriptome profiling and clinical data for CRC from The Cancer Genome Atlas (TCGA) database and obtained the normal colon transcriptome profiling data from Genotype-Tissue Expression Project (GTEx) database. The list of autophagy-related signatures was obtained from the Human Autophagy Database. We isolated the autophagy-related genes from the CRC gene expression matrix and constructed an autophagy-related prognostic (ARP) risk model. Then, we constructed a multiROC curve to validate the prognostic ability of the ARP risk model. CIBERSORT was used to determine the fractions of 22 immune cells iAnalytical cellular pathology (Amsterdam)2055676https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938087biostudies-literatureThe Role of Autophagy in Tumor Immune Infiltration in Colorectal Cancer.PMC8938087Qing-Feng WDong-Ning WYan ZBen-Jun WWen-Wen ZXin DJian-Yu SShi-Yi WBian-Fang YDan TfalseThe Role of Autophagy in Tumor Immune Infiltration in Colorectal Cancer.<h4>Objective</h4>This study is aimed at exploring the association between autophagy and tumor immune infiltration (TII) in colorectal cancer (CRC).<h4>Methods and materials</h4>We downloaded the transcriptome profiling and clinical data for CRC from The Cancer Genome Atlas (TCGA) database and obtained the normal colon transcriptome profiling data from Genotype-Tissue Expression Project (GTEx) database. The list of autophagy-related signatures was obtained from the Human Autophagy Database. We isolated the autophagy-related genes from the CRC gene expression matrix and constructed an autophagy-related prognostic (ARP) risk model. Then, we constructed a multiROC curve to validate the prognostic ability of the ARP risk model. CIBERSORT was used to determine the fractions of 22 immune cells i2022-01-01T00:00:00Z20222025-04-26T04:42:06.182Z2025-04-06T11:12:59.377ZS-EPMC89380873532151610.1155/2022/2055676