{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Emre C"],"funding":["Vetenskapsrådet","Gun och Bertil Stohnes Stiftelse","Stiftelsen för Gamla tjänarinnor; Gun och Bertil Stohnes Stiftelse; Hållstens Forskninsstiftelse; Torsten Söderbergs Stiftelse; EENT Foundation of New Orleans","Stockholms Läns Landsting","Alzheimerfonden"],"pagination":["245"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(1)"],"pubmed_abstract":["Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer's disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the App<sup>NL-G-F/NL-G-F</sup> mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activati"],"journal":["Communications biology"],"pubmed_title":["Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App<sup>NL-G-F/NL-G-F</sup> mice."],"pmcid":["PMC8938447"],"funding_grant_id":["2018-02601"],"pubmed_authors":["Alcalde SG","Ohshima M","Jun B","Emre C","Do KV","Hjorth E","Bazan NG","Maioli S","Cothern ML","Nilsson P","Schultzberg M","Fisahn A","Arroyo-Garcia LE"],"additional_accession":[]},"is_claimable":false,"name":"Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App<sup>NL-G-F/NL-G-F</sup> mice.","description":"Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer's disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the App<sup>NL-G-F/NL-G-F</sup> mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T08:24:20.519Z","creation":"2025-04-04T08:24:20.519Z"},"accession":"S-EPMC8938447","cross_references":{"pubmed":["35314851"],"doi":["10.1038/s42003-022-03169-3"]}}