biostudies-literatureEmre CVetenskapsrådetGun och Bertil Stohnes StiftelseStiftelsen för Gamla tjänarinnor; Gun och Bertil Stohnes Stiftelse; Hållstens Forskninsstiftelse; Torsten Söderbergs Stiftelse; EENT Foundation of New OrleansStockholms Läns LandstingAlzheimerfonden245https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938447biostudies-literatureUnknown5(1)Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer's disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the App^{NL-G-F/NL-G-F} mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activatiCommunications biologyIntranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App^{NL-G-F/NL-G-F} mice.PMC89384472018-02601Alcalde SGOhshima MJun BEmre CDo KVHjorth EBazan NGMaioli SCothern MLNilsson PSchultzberg MFisahn AArroyo-Garcia LEfalseIntranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App^{NL-G-F/NL-G-F} mice.Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer's disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the App^{NL-G-F/NL-G-F} mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activati2022-01-01T00:00:00Z2022 Mar2025-04-04T08:24:20.519Z2025-04-04T08:24:20.519ZS-EPMC89384473531485110.1038/s42003-022-03169-3