biostudies-literatureGallet QMedical Research Council1114-1120https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938511biostudies-literatureUnknown47(5)Recent evidence suggests an association between benzodiazepines (BZDs) use and lower brain amyloid load, a hallmark of AD pathophysiology. Other AD-related markers include hippocampal atrophy, but the effect of BZDs on hippocampal volume remains unclear. We aimed at 1) replicating findings on BZDs use and brain amyloid load and 2) investigating associations between BZDs use and hippocampal volume, in the MEMENTO clinical cohort of nondemented older adults with isolated memory complaint or light cognitive impairment at baseline. Total Standardized Uptake Value Ratio (SUVR) of brain amyloid load and hippocampal volume (HV) were obtained, respectively, from ¹⁸F Florbetapir positron emission tomography (PET) and magnetic resonance imaging (MRI), and compared between BZD chronic userNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyBenzodiazepine use and neuroimaging markers of Alzheimer's disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort.PMC8938511MR/L023784/2MR/T033371/1Gallet QMEMENTO study groupChupin MCottier JPHabert MOBarantin LGohier BBulteau SBelzung CLocatelli MArlicot NDesmidt TRibeiro MJAndersson FDelrieu JSurget AEl-Hage WRobert GGissot VDavid RLebouvier TBouteloup VCamus VBalageas ACfalseBenzodiazepine use and neuroimaging markers of Alzheimer's disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort.Recent evidence suggests an association between benzodiazepines (BZDs) use and lower brain amyloid load, a hallmark of AD pathophysiology. Other AD-related markers include hippocampal atrophy, but the effect of BZDs on hippocampal volume remains unclear. We aimed at 1) replicating findings on BZDs use and brain amyloid load and 2) investigating associations between BZDs use and hippocampal volume, in the MEMENTO clinical cohort of nondemented older adults with isolated memory complaint or light cognitive impairment at baseline. Total Standardized Uptake Value Ratio (SUVR) of brain amyloid load and hippocampal volume (HV) were obtained, respectively, from ¹⁸F Florbetapir positron emission tomography (PET) and magnetic resonance imaging (MRI), and compared between BZD chronic user2022-01-01T00:00:00Z2022 Apr2026-06-19T04:53:07.862Z2025-04-06T00:05:38.282ZS-EPMC89385113489375710.1038/s41386-021-01246-5