biostudies-literatureNestor SMthe Norris Scholar Award and the Labatt Family Network for Research in Depression, Department of Psychiatry, University of TorontoGouvernement du Canada | Canadian Institutes of Health ResearchCIHR1096-1105https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938539biostudies-literatureUnknown47(5)Response to repetitive transcranial magnetic stimulation (rTMS) among individuals with major depressive disorder (MDD) varies widely. The neural mechanisms underlying rTMS are thought to involve changes in large-scale networks. Whether structural network integrity and plasticity are associated with response to rTMS therapy is unclear. Structural MRIs were acquired from a series of 70 adult healthy controls and 268 persons with MDD who participated in two arms of a large randomized, non-inferiority trial, THREE-D, comparing intermittent theta-burst stimulation to high-frequency rTMS of the left dorsolateral prefrontal cortex (DLPFC). Patients were grouped according to percentage improvement on the 17-item Hamilton Depression Rating Score at treatment completion. For the entire sample and thNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyLarge-scale structural network change correlates with clinical response to rTMS in depression.PMC8938539MOP-136801Nestor SMMir-Moghtadaei ADaskalakis ZJBlumberger DMGiacobbe PDownar JVila-Rodriguez FfalseLarge-scale structural network change correlates with clinical response to rTMS in depression.Response to repetitive transcranial magnetic stimulation (rTMS) among individuals with major depressive disorder (MDD) varies widely. The neural mechanisms underlying rTMS are thought to involve changes in large-scale networks. Whether structural network integrity and plasticity are associated with response to rTMS therapy is unclear. Structural MRIs were acquired from a series of 70 adult healthy controls and 268 persons with MDD who participated in two arms of a large randomized, non-inferiority trial, THREE-D, comparing intermittent theta-burst stimulation to high-frequency rTMS of the left dorsolateral prefrontal cortex (DLPFC). Patients were grouped according to percentage improvement on the 17-item Hamilton Depression Rating Score at treatment completion. For the entire sample and th2022-01-01T00:00:00Z2022 Apr2026-07-14T19:07:55.499Z2025-02-18T23:45:09.204ZS-EPMC89385393511068710.1038/s41386-021-01256-3