{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["46"],"submitter":["Karin A"],"pubmed_abstract":["<h4>Background</h4>Obesity is a predominant factor in development of type 2 diabetes but to which extent adolescent obesity influences adult diabetes is unclear. We investigated the association between body mass index (BMI) in young men and subsequent type 2 diabetes and how, in diagnosed diabetes, adolescent BMI relates to glycemic control and diabetes complications.<h4>Methods</h4>Baseline data from the Swedish Conscript Register for men drafted 1968-2005 was combined with data from the National Diabetes and Patient registries. Diabetes risk was estimated through Cox regression and Kaplan-Meier survival estimates. Relationships between BMI, glycemic control and diabetes complications were assessed through multiple linear and logistic regression.<h4>Findings</h4>Among 1,647,826 men, 63,957 (3·88%) developed type 2 diabetes over a median follow-up of 29.0 years (IQR[21.0-37.0]). The risk of diabetes within 40 years after conscription was nearly 40% in individuals with adolescent BMI ≥35 kg/m<sup>2</sup>. Compared to BMI 18·5-<20 kg/m<sup>2</sup> (reference), diabetes risk increased in a linear fashion from HR 1·18(95%CI 1·15-1·21) for BMI 20-<22·5 kg/m<sup>2</sup> to HR 15·93(95%CI 14·88-17·05) for BMI ≥35 kg/m<sup>2</sup>, and a difference in age at onset of 11·4 years was seen. Among men who developed diabetes, higher adolescent BMI was associated with higher HbA1c levels and albuminuria rates.<h4>Interpretation</h4>Rising adolescent BMI was associated with increased risk of type 2 diabetes diagnosed at a younger age, with poorer metabolic control, and a greater prevalence of albuminuria, all suggestive of worse prognosis."],"journal":["EClinicalMedicine"],"pagination":["101356"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938860"],"repository":["biostudies-literature"],"pubmed_title":["Body mass index in adolescence, risk of type 2 diabetes and associated complications: A nationwide cohort study of men."],"pmcid":["PMC8938860"],"pubmed_authors":["Karin A","Martin L","Naveed S","Marcus L","Jon E","Annika R","Maria A","Lena B","Martin A"],"additional_accession":[]},"is_claimable":false,"name":"Body mass index in adolescence, risk of type 2 diabetes and associated complications: A nationwide cohort study of men.","description":"<h4>Background</h4>Obesity is a predominant factor in development of type 2 diabetes but to which extent adolescent obesity influences adult diabetes is unclear. We investigated the association between body mass index (BMI) in young men and subsequent type 2 diabetes and how, in diagnosed diabetes, adolescent BMI relates to glycemic control and diabetes complications.<h4>Methods</h4>Baseline data from the Swedish Conscript Register for men drafted 1968-2005 was combined with data from the National Diabetes and Patient registries. Diabetes risk was estimated through Cox regression and Kaplan-Meier survival estimates. Relationships between BMI, glycemic control and diabetes complications were assessed through multiple linear and logistic regression.<h4>Findings</h4>Among 1,647,826 men, 63,957 (3·88%) developed type 2 diabetes over a median follow-up of 29.0 years (IQR[21.0-37.0]). The risk of diabetes within 40 years after conscription was nearly 40% in individuals with adolescent BMI ≥35 kg/m<sup>2</sup>. Compared to BMI 18·5-<20 kg/m<sup>2</sup> (reference), diabetes risk increased in a linear fashion from HR 1·18(95%CI 1·15-1·21) for BMI 20-<22·5 kg/m<sup>2</sup> to HR 15·93(95%CI 14·88-17·05) for BMI ≥35 kg/m<sup>2</sup>, and a difference in age at onset of 11·4 years was seen. Among men who developed diabetes, higher adolescent BMI was associated with higher HbA1c levels and albuminuria rates.<h4>Interpretation</h4>Rising adolescent BMI was associated with increased risk of type 2 diabetes diagnosed at a younger age, with poorer metabolic control, and a greater prevalence of albuminuria, all suggestive of worse prognosis.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T20:51:03.16Z","creation":"2025-04-04T20:51:03.16Z"},"accession":"S-EPMC8938860","cross_references":{"pubmed":["35330801"],"doi":["10.1016/j.eclinm.2022.101356"]}}