biostudies-literatureUnknown46Karin A<h4>Background</h4>Obesity is a predominant factor in development of type 2 diabetes but to which extent adolescent obesity influences adult diabetes is unclear. We investigated the association between body mass index (BMI) in young men and subsequent type 2 diabetes and how, in diagnosed diabetes, adolescent BMI relates to glycemic control and diabetes complications.<h4>Methods</h4>Baseline data from the Swedish Conscript Register for men drafted 1968-2005 was combined with data from the National Diabetes and Patient registries. Diabetes risk was estimated through Cox regression and Kaplan-Meier survival estimates. Relationships between BMI, glycemic control and diabetes complications were assessed through multiple linear and logistic regression.<h4>Findings</h4>Among 1,647,826 men, 63,957 (3·88%) developed type 2 diabetes over a median follow-up of 29.0 years (IQR[21.0-37.0]). The risk of diabetes within 40 years after conscription was nearly 40% in individuals with adolescent BMI ≥35 kg/m². Compared to BMI 18·5-<20 kg/m² (reference), diabetes risk increased in a linear fashion from HR 1·18(95%CI 1·15-1·21) for BMI 20-<22·5 kg/m² to HR 15·93(95%CI 14·88-17·05) for BMI ≥35 kg/m², and a difference in age at onset of 11·4 years was seen. Among men who developed diabetes, higher adolescent BMI was associated with higher HbA1c levels and albuminuria rates.<h4>Interpretation</h4>Rising adolescent BMI was associated with increased risk of type 2 diabetes diagnosed at a younger age, with poorer metabolic control, and a greater prevalence of albuminuria, all suggestive of worse prognosis.EClinicalMedicine101356https://www.ebi.ac.uk/biostudies/studies/S-EPMC8938860biostudies-literatureBody mass index in adolescence, risk of type 2 diabetes and associated complications: A nationwide cohort study of men.PMC8938860Karin AMartin LNaveed SMarcus LJon EAnnika RMaria ALena BMartin AfalseBody mass index in adolescence, risk of type 2 diabetes and associated complications: A nationwide cohort study of men.<h4>Background</h4>Obesity is a predominant factor in development of type 2 diabetes but to which extent adolescent obesity influences adult diabetes is unclear. We investigated the association between body mass index (BMI) in young men and subsequent type 2 diabetes and how, in diagnosed diabetes, adolescent BMI relates to glycemic control and diabetes complications.<h4>Methods</h4>Baseline data from the Swedish Conscript Register for men drafted 1968-2005 was combined with data from the National Diabetes and Patient registries. Diabetes risk was estimated through Cox regression and Kaplan-Meier survival estimates. Relationships between BMI, glycemic control and diabetes complications were assessed through multiple linear and logistic regression.<h4>Findings</h4>Among 1,647,826 men, 63,957 (3·88%) developed type 2 diabetes over a median follow-up of 29.0 years (IQR[21.0-37.0]). The risk of diabetes within 40 years after conscription was nearly 40% in individuals with adolescent BMI ≥35 kg/m². Compared to BMI 18·5-<20 kg/m² (reference), diabetes risk increased in a linear fashion from HR 1·18(95%CI 1·15-1·21) for BMI 20-<22·5 kg/m² to HR 15·93(95%CI 14·88-17·05) for BMI ≥35 kg/m², and a difference in age at onset of 11·4 years was seen. Among men who developed diabetes, higher adolescent BMI was associated with higher HbA1c levels and albuminuria rates.<h4>Interpretation</h4>Rising adolescent BMI was associated with increased risk of type 2 diabetes diagnosed at a younger age, with poorer metabolic control, and a greater prevalence of albuminuria, all suggestive of worse prognosis.2022-01-01T00:00:00Z2022 Apr2025-04-04T20:51:03.16Z2025-04-04T20:51:03.16ZS-EPMC89388603533080110.1016/j.eclinm.2022.101356