{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee KY"],"funding":["NCATS NIH HHS","NHLBI NIH HHS"],"pagination":["639-647"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8939435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["375(6581)"],"pubmed_abstract":["Biohybrid systems have been developed to better understand the design principles and coordination mechanisms of biological systems. We consider whether two functional regulatory features of the heart-mechanoelectrical signaling and automaticity-could be transferred to a synthetic analog of another fluid transport system: a swimming fish. By leveraging cardiac mechanoelectrical signaling, we recreated reciprocal contraction and relaxation in a muscular bilayer construct where each contraction occurs automatically as a response to the stretching of an antagonistic muscle pair. Further, to entrain this closed-loop actuation cycle, we engineered an electrically autonomous pacing node, which enhanced spontaneous contraction. The biohybrid fish equipped with intrinsic control strategies demonstrated self-sustained body-caudal fin swimming, highlighting the role of feedback mechanisms in muscular pumps such as the heart and muscles."],"journal":["Science (New York, N.Y.)"],"pubmed_title":["An autonomously swimming biohybrid fish designed with human cardiac biophysics."],"pmcid":["PMC8939435"],"funding_grant_id":["UH3 HL141798","UH3 TR000522","UG3 HL141798"],"pubmed_authors":["Ardona HAM","Kleber AG","Lauder GV","Lee KY","Parker KK","Park SJ","Matthews DG","Marquez CA","Zimmerman JF","Kim SL"],"additional_accession":[]},"is_claimable":false,"name":"An autonomously swimming biohybrid fish designed with human cardiac biophysics.","description":"Biohybrid systems have been developed to better understand the design principles and coordination mechanisms of biological systems. We consider whether two functional regulatory features of the heart-mechanoelectrical signaling and automaticity-could be transferred to a synthetic analog of another fluid transport system: a swimming fish. By leveraging cardiac mechanoelectrical signaling, we recreated reciprocal contraction and relaxation in a muscular bilayer construct where each contraction occurs automatically as a response to the stretching of an antagonistic muscle pair. Further, to entrain this closed-loop actuation cycle, we engineered an electrically autonomous pacing node, which enhanced spontaneous contraction. The biohybrid fish equipped with intrinsic control strategies demonstrated self-sustained body-caudal fin swimming, highlighting the role of feedback mechanisms in muscular pumps such as the heart and muscles.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-19T09:21:19.769Z","creation":"2025-04-19T09:21:19.769Z"},"accession":"S-EPMC8939435","cross_references":{"pubmed":["35143298"],"doi":["10.1126/science.abh0474"]}}