biostudies-literatureYeung MWMedical Research Council484-501https://www.ebi.ac.uk/biostudies/studies/S-EPMC8939707biostudies-literatureUnknown42(4)<h4>Objective</h4>Carotid artery intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and the identification of additional susceptibility loci furthers our knowledge on the genetic architecture underlying atherosclerosis.<h4>Approach and results</h4>We performed 3 genome-wide association studies in 45 185 participants from the UK Biobank study who underwent cIMT measurements and had data on minimum, mean, and maximum thickness. We replicated 15 known loci and identified 20 novel loci associated with cIMT at <i>P</i><5×10^-8. Seven novel loci (<i>ZNF385D</i>, AD<i>AMTS9</i>, <i>EDNRA</i>, <i>HAND2</i>, <i>MYOCD</i>, <i>ITCH/EDEM2/MMP24</i>, and <i>MRTFA</i>) were identified in all 3Arteriosclerosis, thrombosis, and vascular biologyTwenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in &gt;45 000 Individuals and Meta-Analysis of &gt;100 000 Individuals.PMC8939707MC_PC_17228MC_QA137853van der Harst Pvan de Vegte YJvan Setten JWang SBorisov OYeung MWSnieder HVerweij NSaid MAfalseTwenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in &gt;45 000 Individuals and Meta-Analysis of &gt;100 000 Individuals.<h4>Objective</h4>Carotid artery intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and the identification of additional susceptibility loci furthers our knowledge on the genetic architecture underlying atherosclerosis.<h4>Approach and results</h4>We performed 3 genome-wide association studies in 45 185 participants from the UK Biobank study who underwent cIMT measurements and had data on minimum, mean, and maximum thickness. We replicated 15 known loci and identified 20 novel loci associated with cIMT at <i>P</i><5×10^-8. Seven novel loci (<i>ZNF385D</i>, AD<i>AMTS9</i>, <i>EDNRA</i>, <i>HAND2</i>, <i>MYOCD</i>, <i>ITCH/EDEM2/MMP24</i>, and <i>MRTFA</i>) were identified in all 32022-01-01T00:00:00Z2022 Apr2026-05-09T14:25:15.902Z2025-04-06T19:37:36.095ZS-EPMC89397073485264310.1161/ATVBAHA.121.317007