{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Chen X"],"funding":["Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China","Ningbo Municipal Bureau of Science and Technology"],"pubmed_abstract":["Refractory bone fracture, which is difficult to be treated, is a common clinical disease. Taking inspiration from the natural process of bone regeneration, we provide a biomimetic strategy to develop a new injectable biomaterial for repairing bone defects, which is mainly composed of platelets, fibrins, and biominerals. Biomineral nanoparticles (EACPNs) with an amorphous phase are prepared by an enzyme-catalyzed route and display a platelet-activating property. The composite hydrogel (EPH) of EACPNs, fibrins, and platelets is injectable, and has similar chemical properties to natural materials in bone regeneration. The dried EPH samples display a highly porous structure, which would be favorable for cell attachment and growth. The results from <i>in vitro</i> studies indicate that EPH has "],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["826855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8940219"],"repository":["biostudies-literature"],"pubmed_title":["Platelet-Activating Biominerals Enhanced Injectable Hydrogels With Superior Bioactivity for Bone Regeneration."],"pmcid":["PMC8940219"],"pubmed_authors":["Jiang Y","Liu J","He S","Yan J","Fan Y","Ying Z","Tan S","Chen F","Chen X","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"Platelet-Activating Biominerals Enhanced Injectable Hydrogels With Superior Bioactivity for Bone Regeneration.","description":"Refractory bone fracture, which is difficult to be treated, is a common clinical disease. Taking inspiration from the natural process of bone regeneration, we provide a biomimetic strategy to develop a new injectable biomaterial for repairing bone defects, which is mainly composed of platelets, fibrins, and biominerals. Biomineral nanoparticles (EACPNs) with an amorphous phase are prepared by an enzyme-catalyzed route and display a platelet-activating property. The composite hydrogel (EPH) of EACPNs, fibrins, and platelets is injectable, and has similar chemical properties to natural materials in bone regeneration. The dried EPH samples display a highly porous structure, which would be favorable for cell attachment and growth. The results from <i>in vitro</i> studies indicate that EPH has ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T12:54:07.319Z","creation":"2025-04-19T12:54:07.319Z"},"accession":"S-EPMC8940219","cross_references":{"pubmed":["35330625"],"doi":["10.3389/fbioe.2022.826855"]}}