{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhou JW"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["The natural product 4-hydroxycinnamic acid (HA) was firstly isolated from the metabolites of <i>Phomopsis liquidambari</i>, one endophytic fungus from <i>Punica granatum</i> leaves. The anti-QS potential of HA was evaluated by β-galactosidase assay and acylated homoserine lactones (AHL) analysis. The MIC of HA was > 1.20 mM. Exposure to HA at sub-MIC concentrations (0.30-0.60 mM) remarkably reduced the β-galactosidase activity and AHL secretion. Transcriptional analysis by qRT-PCR and docking simulation indicated that HA functions as an anti-QS agent by inhibiting the transcriptional levels of <i>traI</i> and <i>traR</i> rather than signal mimicry. The blocked QS lead to suppressed biofilm formation, motilities, and flagella formation after exposure to HA at concentrations ranging from 0.3"],"journal":["Frontiers in microbiology"],"pagination":["830632"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8940537"],"repository":["biostudies-literature"],"pubmed_title":["Quorum Sensing Inhibition and Metabolic Intervention of 4-Hydroxycinnamic Acid Against <i>Agrobacterium tumefaciens</i>."],"pmcid":["PMC8940537"],"pubmed_authors":["Tan XJ","Zhou JW","Jia AQ","Ji PC","Jiang H"],"additional_accession":[]},"is_claimable":false,"name":"Quorum Sensing Inhibition and Metabolic Intervention of 4-Hydroxycinnamic Acid Against <i>Agrobacterium tumefaciens</i>.","description":"The natural product 4-hydroxycinnamic acid (HA) was firstly isolated from the metabolites of <i>Phomopsis liquidambari</i>, one endophytic fungus from <i>Punica granatum</i> leaves. The anti-QS potential of HA was evaluated by β-galactosidase assay and acylated homoserine lactones (AHL) analysis. The MIC of HA was > 1.20 mM. Exposure to HA at sub-MIC concentrations (0.30-0.60 mM) remarkably reduced the β-galactosidase activity and AHL secretion. Transcriptional analysis by qRT-PCR and docking simulation indicated that HA functions as an anti-QS agent by inhibiting the transcriptional levels of <i>traI</i> and <i>traR</i> rather than signal mimicry. The blocked QS lead to suppressed biofilm formation, motilities, and flagella formation after exposure to HA at concentrations ranging from 0.3","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T21:46:13.673Z","creation":"2025-04-19T21:46:13.673Z"},"accession":"S-EPMC8940537","cross_references":{"pubmed":["35330766"],"doi":["10.3389/fmicb.2022.830632"]}}