biostudies-literatureAlajlouni DNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Center for Advancing Translational SciencesNCATS NIH HHSNIH Roadmap for Medical ResearchNIA NIH HHSAustralian Government Research Training ProgramAustralian Medical Research Futures FundNational Institutes of HealthNIAMS NIH HHSNational Institute on Aging411-419https://www.ebi.ac.uk/biostudies/studies/S-EPMC8940659biostudies-literatureUnknown37(3)Muscle strength and physical performance are associated with fracture risk in men. However, it is not known whether these measurements enhance fracture prediction beyond Garvan and FRAX tools. A total of 5665 community-dwelling men, aged ≥65 years, from the Osteoporotic Fractures in Men (MrOS) Study, who had data on muscle strength (grip strength) and physical performance (gait speed and chair stand tests), were followed from 2000 to 2019 for any fracture, major osteoporotic fracture (MOF), initial hip, and any hip fracture. The contributions to different fracture outcomes were assessed using Cox's proportional hazard models. Tool-specific analysis approaches and outcome definitions were used. The added predictive values of muscle strength and physical performance beyond Garvan and FRAX weJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchMuscle Strength and Physical Performance Improve Fracture Risk Prediction Beyond Garvan and FRAX: The Osteoporotic Fractures in Men (MrOS) Study.PMC8940659U01 AG042139U01 AG042124U01 AG042168U01 AG042145UL1 TR000128UL1 TR002369U01 AG042143U01 AG027810U01 AG042140R01 AG066671U01 AR0661601137462R56 AG061085Center JRTran TOrwoll ESBliuc DAlajlouni DBlank RDCawthon PMfalseMuscle Strength and Physical Performance Improve Fracture Risk Prediction Beyond Garvan and FRAX: The Osteoporotic Fractures in Men (MrOS) Study.Muscle strength and physical performance are associated with fracture risk in men. However, it is not known whether these measurements enhance fracture prediction beyond Garvan and FRAX tools. A total of 5665 community-dwelling men, aged ≥65 years, from the Osteoporotic Fractures in Men (MrOS) Study, who had data on muscle strength (grip strength) and physical performance (gait speed and chair stand tests), were followed from 2000 to 2019 for any fracture, major osteoporotic fracture (MOF), initial hip, and any hip fracture. The contributions to different fracture outcomes were assessed using Cox's proportional hazard models. Tool-specific analysis approaches and outcome definitions were used. The added predictive values of muscle strength and physical performance beyond Garvan and FRAX we2022-01-01T00:00:00Z2022 Mar2025-04-04T21:43:52.239Z2025-04-04T21:43:52.239ZS-EPMC89406593484230910.1002/jbmr.4483