{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thurston RC"],"funding":["NCATS NIH HHS","NIA NIH HHS","NCRR NIH HHS","NIMH NIH HHS","NHLBI NIH HHS"],"pagination":["773-780"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8940746"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(2)"],"pubmed_abstract":["Traumatic experiences have been linked to poor mental and physical health. However, there has been little examination of their relationship to neuroimaging markers of cerebrovascular risk. White matter hyperintensities (WMHs) are markers of brain small vessel disease. WMHs can be detected decades before the onset of dementia and other disorders and can serve as early markers for these brain disorders. We tested whether traumatic experiences were associated with brain WMH volume among midlife women. In the MsBrain study, 145 women (mean age = 59 years) without cardiovascular disease, stroke, or dementia were recruited. Women completed questionnaires [trauma checklist, depression, post-traumatic stress measures]; physical measures [body mass index (BMI), blood pressure (BP)]; phlebotomy; act"],"journal":["Brain imaging and behavior"],"pubmed_title":["Sexual assault and white matter hyperintensities among midlife women."],"pmcid":["PMC8940746"],"funding_grant_id":["R01 MH101269","T32 MH018269","R01 AG053504","RF1 AG053504","K24 HL123565","R01 HL105647","UL1 TR000005","S10 RR023461"],"pubmed_authors":["Wu M","Maki PM","Barinas-Mitchell E","Aizenstein HJ","Koenen KC","Thurston RC","Derby CA","Chang Y","Jakubowski KP"],"additional_accession":[]},"is_claimable":false,"name":"Sexual assault and white matter hyperintensities among midlife women.","description":"Traumatic experiences have been linked to poor mental and physical health. However, there has been little examination of their relationship to neuroimaging markers of cerebrovascular risk. White matter hyperintensities (WMHs) are markers of brain small vessel disease. WMHs can be detected decades before the onset of dementia and other disorders and can serve as early markers for these brain disorders. We tested whether traumatic experiences were associated with brain WMH volume among midlife women. In the MsBrain study, 145 women (mean age = 59 years) without cardiovascular disease, stroke, or dementia were recruited. Women completed questionnaires [trauma checklist, depression, post-traumatic stress measures]; physical measures [body mass index (BMI), blood pressure (BP)]; phlebotomy; act","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-21T22:33:54.563Z","creation":"2025-04-05T18:52:06.722Z"},"accession":"S-EPMC8940746","cross_references":{"pubmed":["34553332"],"doi":["10.1007/s11682-021-00536-2"]}}