{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(5)"],"submitter":["Wang L"],"pubmed_abstract":["Throughout the world, numerous individuals are infected with <i>Toxoplasma gondii</i>, which may improve immunity against cancer. Furthermore, microRNAs (miRs) may be differentially expressed in the host upon infection with <i>T. gondii</i>. In the present study, RNA-sequencing analysis and reverse transcription-quantitative PCR revealed that miR-429-3p, miR-145a-5p, miR-211-5p, miR-31-3p and miR-135a-5p were determined to be downregulated, while miR-21a-3p, miR-135b-5p, miR-210-5p and miR-146-3p were upregulated in mice post-infection with <i>T. gondii</i>. Antitumor genes [TNF receptor superfamily member 11b, large tumor suppressor kinase (Lats)2 and Lats1] were identified as targets of miR-429-3p, miR-145a-5p, miR-211-5p, miR-31-3p and miR-135a-5p with a luciferase reporter assay. In ad"],"journal":["Oncology letters"],"pagination":["149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8941548"],"repository":["biostudies-literature"],"pubmed_title":["<i>Toxoplasma gondii</i> causes changes in the host's expression of cancer-associated miRNAs."],"pmcid":["PMC8941548"],"pubmed_authors":["Wang N","Zhao YH","Lu G","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"<i>Toxoplasma gondii</i> causes changes in the host's expression of cancer-associated miRNAs.","description":"Throughout the world, numerous individuals are infected with <i>Toxoplasma gondii</i>, which may improve immunity against cancer. Furthermore, microRNAs (miRs) may be differentially expressed in the host upon infection with <i>T. gondii</i>. In the present study, RNA-sequencing analysis and reverse transcription-quantitative PCR revealed that miR-429-3p, miR-145a-5p, miR-211-5p, miR-31-3p and miR-135a-5p were determined to be downregulated, while miR-21a-3p, miR-135b-5p, miR-210-5p and miR-146-3p were upregulated in mice post-infection with <i>T. gondii</i>. Antitumor genes [TNF receptor superfamily member 11b, large tumor suppressor kinase (Lats)2 and Lats1] were identified as targets of miR-429-3p, miR-145a-5p, miR-211-5p, miR-31-3p and miR-135a-5p with a luciferase reporter assay. In ad","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T18:19:22.625Z","creation":"2025-04-06T02:23:11.541Z"},"accession":"S-EPMC8941548","cross_references":{"pubmed":["35350589"],"doi":["10.3892/ol.2022.13267"]}}