{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wan ES"],"funding":["NHLBI","NHLBI NIH HHS","RRD VA","NLM NIH HHS","US Department of Veterans Affairs"],"pagination":["651-661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8941606"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["161(3)"],"pubmed_abstract":["<h4>Background</h4>Emerging data from longitudinal studies suggest that preserved ratio impaired spirometry (PRISm), defined by proportionate reductions in FEV<sub>1</sub> and FVC, is a heterogeneous population with frequent transitions to other lung function categories relative to individuals with normal and obstructive spirometry. Controversy regarding the clinical significance of these transitions exists (eg, whether transitions merely reflect measurement variability or noise).<h4>Research question</h4>Are individuals with PRISm enriched for transitions associated with substantial changes in lung function?<h4>Study design and methods</h4>Current and former smokers enrolled in the Genetic Epidemiology of COPD (COPDGene) study with spirometry available in phases 1 through 3 (enrollment, 5"],"journal":["Chest"],"pubmed_title":["Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers."],"pmcid":["PMC8941606"],"funding_grant_id":["R01 HL089856","U01 HL089897","IK2 RX002165","U01 HL089856","R21 LM013670","R21 HL140422","R01 HL149877","R01 HL089897"],"pubmed_authors":["Crapo JD","Make BJ","Wan ES","Mason SE","San Jose Estepar R","Regan EA","Hokanson JE","Silverman EK","Young KA","DeMeo DL"],"additional_accession":[]},"is_claimable":false,"name":"Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers.","description":"<h4>Background</h4>Emerging data from longitudinal studies suggest that preserved ratio impaired spirometry (PRISm), defined by proportionate reductions in FEV<sub>1</sub> and FVC, is a heterogeneous population with frequent transitions to other lung function categories relative to individuals with normal and obstructive spirometry. Controversy regarding the clinical significance of these transitions exists (eg, whether transitions merely reflect measurement variability or noise).<h4>Research question</h4>Are individuals with PRISm enriched for transitions associated with substantial changes in lung function?<h4>Study design and methods</h4>Current and former smokers enrolled in the Genetic Epidemiology of COPD (COPDGene) study with spirometry available in phases 1 through 3 (enrollment, 5","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T07:33:45.08Z","creation":"2025-04-19T07:33:45.08Z"},"accession":"S-EPMC8941606","cross_references":{"pubmed":["34592319"],"doi":["10.1016/j.chest.2021.09.021"]}}