{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cornejo VH"],"funding":["NEI NIH HHS","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["82-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8942082"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["375(6576)"],"pubmed_abstract":["Dendritic spines mediate most excitatory neurotransmission in the nervous system, so their function must be critical for the brain. Spines are biochemical compartments but might also electrically modify synaptic potentials. Using two-photon microscopy and a genetically encoded voltage indicator, we measured membrane potentials in spines and dendrites from pyramidal neurons in the somatosensory cortex of mice during spontaneous activity and sensory stimulation. Spines and dendrites were depolarized together during action potentials, but, during subthreshold and resting potentials, spines often experienced different voltages than parent dendrites, even activating independently. Spine voltages remained compartmentalized after two-photon optogenetic activation of individual spine heads. We con"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Voltage compartmentalization in dendritic spines in vivo."],"pmcid":["PMC8942082"],"funding_grant_id":["R01 MH115900","R01 EY011787","R34 NS116740","R01 NS110422"],"pubmed_authors":["Yuste R","Ofer N","Cornejo VH"],"additional_accession":[]},"is_claimable":false,"name":"Voltage compartmentalization in dendritic spines in vivo.","description":"Dendritic spines mediate most excitatory neurotransmission in the nervous system, so their function must be critical for the brain. Spines are biochemical compartments but might also electrically modify synaptic potentials. Using two-photon microscopy and a genetically encoded voltage indicator, we measured membrane potentials in spines and dendrites from pyramidal neurons in the somatosensory cortex of mice during spontaneous activity and sensory stimulation. Spines and dendrites were depolarized together during action potentials, but, during subthreshold and resting potentials, spines often experienced different voltages than parent dendrites, even activating independently. Spine voltages remained compartmentalized after two-photon optogenetic activation of individual spine heads. We con","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-19T12:54:09.4Z","creation":"2025-04-19T12:54:09.4Z"},"accession":"S-EPMC8942082","cross_references":{"pubmed":["34762487"],"doi":["10.1126/science.abg0501"]}}