{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kumari A"],"funding":["Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India"],"pagination":["320-326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8942235"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["2-Arylquinazolines with a range of alkyl polyamines as side chain/ring functional motifs at the 4th-position were considered for antileishmanial study with the rationale that related heterocyclic scaffolds and polyamine functionalities are present in drugs, clinical trial agents, natural products and anti-parasitic/leishmanial agents. Synthesis involves construction of the 2-arylquinazolin-4-one ring and deoxyamination <i>via</i> deoxychlorination followed by S<sub>N</sub>Ar-based amination or a methodology of S<sub>N</sub>Ar-deoxyamination driven by BOP-mediated hydroxyl-activation. Various alkyl-polyamines important for activities were incorporated. A total of 26 compounds were prepared and screened against <i>Leishmania donovani</i> (<i>Ld</i>) promastigote cells using the MTT assay. Mo"],"journal":["RSC medicinal chemistry"],"pubmed_title":["Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies."],"pmcid":["PMC8942235"],"funding_grant_id":["KA-01"],"pubmed_authors":["Acharya A","Kumar V","Kumar G","Jaiswal T","Babu NK","Hura N","Kumari A","Guchhait SK","Singh S","Roy PK"],"additional_accession":[]},"is_claimable":false,"name":"Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies.","description":"2-Arylquinazolines with a range of alkyl polyamines as side chain/ring functional motifs at the 4th-position were considered for antileishmanial study with the rationale that related heterocyclic scaffolds and polyamine functionalities are present in drugs, clinical trial agents, natural products and anti-parasitic/leishmanial agents. Synthesis involves construction of the 2-arylquinazolin-4-one ring and deoxyamination <i>via</i> deoxychlorination followed by S<sub>N</sub>Ar-based amination or a methodology of S<sub>N</sub>Ar-deoxyamination driven by BOP-mediated hydroxyl-activation. Various alkyl-polyamines important for activities were incorporated. A total of 26 compounds were prepared and screened against <i>Leishmania donovani</i> (<i>Ld</i>) promastigote cells using the MTT assay. Mo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-22T04:27:01.579Z","creation":"2025-04-05T21:00:31.312Z"},"accession":"S-EPMC8942235","cross_references":{"pubmed":["35434631"],"doi":["10.1039/d1md00336d"]}}