{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gebrecherkos T"],"funding":["European & Developing Countries Clinical Trials Partnership (EDCTP)"],"pagination":["e0263627"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8942258"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(3)"],"pubmed_abstract":["<h4>Background</h4>Serological testing for SARS-CoV-2 plays an important role for epidemiological studies, in aiding the diagnosis of COVID-19, and assess vaccine responses. Little is known on dynamics of SARS-CoV-2 serology in African settings. Here, we aimed to characterize the longitudinal antibody response profile to SARS-CoV-2 in Ethiopia.<h4>Methods</h4>In this prospective study, a total of 102 PCR-confirmed COVID-19 patients were enrolled. We obtained 802 plasma samples collected serially. SARS-CoV-2 antibodies were determined using four lateral flow immune-assays (LFIAs), and an electrochemiluminescent immunoassay. We determined longitudinal antibody response to SARS-CoV-2 as well as seroconversion dynamics.<h4>Results</h4>Serological positivity rate ranged between 12%-91%, dependi"],"journal":["PloS one"],"pubmed_title":["Longitudinal profile of antibody response to SARS-CoV-2 in patients with COVID-19 in a setting from Sub-Saharan Africa: A prospective longitudinal study."],"pmcid":["PMC8942258"],"funding_grant_id":["RIA-2020EF-2095"],"pubmed_authors":["Abdulkader M","Urban BC","Tessema M","Kiros YK","Kifle T","Tollera G","Challa F","Tasew G","Desta A","de Wit TFR","Abdella S","Gebrecherkos T","Schallig HH","Wolday D","Hailu A","Gebreegzabher A","Leta D","Arefaine ZG","Adams ER"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal profile of antibody response to SARS-CoV-2 in patients with COVID-19 in a setting from Sub-Saharan Africa: A prospective longitudinal study.","description":"<h4>Background</h4>Serological testing for SARS-CoV-2 plays an important role for epidemiological studies, in aiding the diagnosis of COVID-19, and assess vaccine responses. Little is known on dynamics of SARS-CoV-2 serology in African settings. Here, we aimed to characterize the longitudinal antibody response profile to SARS-CoV-2 in Ethiopia.<h4>Methods</h4>In this prospective study, a total of 102 PCR-confirmed COVID-19 patients were enrolled. We obtained 802 plasma samples collected serially. SARS-CoV-2 antibodies were determined using four lateral flow immune-assays (LFIAs), and an electrochemiluminescent immunoassay. We determined longitudinal antibody response to SARS-CoV-2 as well as seroconversion dynamics.<h4>Results</h4>Serological positivity rate ranged between 12%-91%, dependi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T01:00:12.667Z","creation":"2025-05-18T12:30:53.735Z"},"accession":"S-EPMC8942258","cross_references":{"pubmed":["35320286"],"doi":["10.1371/journal.pone.0263627"]}}