{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(6)"],"submitter":["Cai B"],"funding":["funding"],"pubmed_abstract":["Nasopharyngeal carcinoma (NPC) has a low five-year survival rate, and its pathogenesis remains unclear. There is an urgent need to improve our understanding of the genetic regulation of NPC tumorigenesis and development. The role of miR-26a-5p in NPC growth regulation and the expression of its target, PTGS2, was analyzed. Quantitative Real-time PCR assay was used to detect miR-26a-5p and PTGS2 expression in human NPC tissues and cell lines. The RNA pull-down dual-luciferase reporter assay was used to determine the association between miR-26a-5p and PTGS2. The effects of miR-26a-5p and PTGS2 on NPC cell viability, proliferation, migration, and invasion were measured by CCK-8, BrdU, and Transwell assays. miR-26a-5p expression in NPC tissues and cell lines was significantly decreased. The overexpression of miR-26a-5p inhibited the viability, proliferation, migration, and invasion of NPC cells. miR-26a-5p bound to the 3-'untranslated region of PTGS2, thus reducing PTGS2 protein levels. miR-26a-5p inhibited NPC development by reducing the expression of its target PTGS2."],"journal":["Cell cycle (Georgetown, Tex.)"],"pagination":["618-629"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8942422"],"repository":["biostudies-literature"],"pubmed_title":["miR-26a-5p suppresses nasopharyngeal carcinoma progression by inhibiting PTGS2 expression."],"pmcid":["PMC8942422"],"pubmed_authors":["Cai B","Kan D","Qu X","Luo Y"],"additional_accession":[]},"is_claimable":false,"name":"miR-26a-5p suppresses nasopharyngeal carcinoma progression by inhibiting PTGS2 expression.","description":"Nasopharyngeal carcinoma (NPC) has a low five-year survival rate, and its pathogenesis remains unclear. There is an urgent need to improve our understanding of the genetic regulation of NPC tumorigenesis and development. The role of miR-26a-5p in NPC growth regulation and the expression of its target, PTGS2, was analyzed. Quantitative Real-time PCR assay was used to detect miR-26a-5p and PTGS2 expression in human NPC tissues and cell lines. The RNA pull-down dual-luciferase reporter assay was used to determine the association between miR-26a-5p and PTGS2. The effects of miR-26a-5p and PTGS2 on NPC cell viability, proliferation, migration, and invasion were measured by CCK-8, BrdU, and Transwell assays. miR-26a-5p expression in NPC tissues and cell lines was significantly decreased. The overexpression of miR-26a-5p inhibited the viability, proliferation, migration, and invasion of NPC cells. miR-26a-5p bound to the 3-'untranslated region of PTGS2, thus reducing PTGS2 protein levels. miR-26a-5p inhibited NPC development by reducing the expression of its target PTGS2.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar-Mar","modification":"2026-06-19T03:17:32.584Z","creation":"2025-04-21T16:58:26.881Z"},"accession":"S-EPMC8942422","cross_references":{"pubmed":["35073820"],"doi":["10.1080/15384101.2022.2030168"]}}