biostudies-literatureBurugupalli SNational Health and Medical Research Councile72779https://www.ebi.ac.uk/biostudies/studies/S-EPMC8942471biostudies-literatureUnknown11<h4>Background</h4>There is mounting evidence that in utero and early life exposures may predispose an individual to metabolic disorders in later life; and dysregulation of lipid metabolism is critical in such outcomes. However, there is limited knowledge about lipid metabolism and factors causing lipid dysregulation in early life that could result in adverse health outcomes in later life. We studied the effect of antenatal factors such as gestational age, birth weight, and mode of birth on lipid metabolism at birth; changes in the circulating lipidome in the first 4 years of life and the effect of breastfeeding in the first year of life. From this study, we aim to generate a framework for deeper understanding into factors effecting lipid metabolism in early life, to provide early interveneLifeOntogeny of circulating lipid metabolism in pregnancy and early childhood - a longitudinal population study.PMC8942471A*STAR-NHMRC joint call funding (1711624031).Burgner DMellett NGeorge APaul SSmith AATBurugupalli SMeikle PCarlin JTang MGiles CSly PHuynh KDuong TDwyer TWang TCinel MOshlensky GMir SACollier FSaffery RChen LWenk MRVuillermin PAllen KPonsonby ALNguyen AKarnani NBarwon Infant Study Investigator teamRanganathan SfalseOntogeny of circulating lipid metabolism in pregnancy and early childhood - a longitudinal population study.<h4>Background</h4>There is mounting evidence that in utero and early life exposures may predispose an individual to metabolic disorders in later life; and dysregulation of lipid metabolism is critical in such outcomes. However, there is limited knowledge about lipid metabolism and factors causing lipid dysregulation in early life that could result in adverse health outcomes in later life. We studied the effect of antenatal factors such as gestational age, birth weight, and mode of birth on lipid metabolism at birth; changes in the circulating lipidome in the first 4 years of life and the effect of breastfeeding in the first year of life. From this study, we aim to generate a framework for deeper understanding into factors effecting lipid metabolism in early life, to provide early interven2022-01-01T00:00:00Z2022 Mar2026-03-15T19:13:26.406Z2025-04-04T23:33:45.155ZS-EPMC89424713523461110.7554/eLife.72779