biostudies-literatureKambeitz-Ilankovic LNIMH NIH HHSthe EU-FP7 project PRONIA828-845https://www.ebi.ac.uk/biostudies/studies/S-EPMC8942567biostudies-literatureUnknown107Cognitive remediation (CR) is nowadays mainly administered in a computerized fashion, yet frequently supplemented by human guidance. The effects of CR on cognitive, functional and clinical outcomes are consistently reported, yet the response is heterogeneous. In order to resolve this heterogeneity, we employed a multi-outcome meta-analytic approach, examined effects of CR on each outcome category separately and estimated directed effects between three outcome categories. We extracted treatment effects from 67 studies that trained patients with schizophrenia (total n = 4067) using either 1) computerized CR modality alone or 2) in combination with supplementary human guidance (SHG). All three outcome domains were significantly improved by CR with small to moderate effect sizes when assessingNeuroscience and biobehavioral reviewsMulti-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: Revisiting the relevance of human coaching and elucidating interplay between multiple outcomes.PMC8942567602152R01 MH122897K01 MH105615Betz LTDominke CKambeitz JSubramaniam KFisher MHaas SSKambeitz-Ilankovic LKoutsouleris NVinogradov SfalseMulti-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: Revisiting the relevance of human coaching and elucidating interplay between multiple outcomes.Cognitive remediation (CR) is nowadays mainly administered in a computerized fashion, yet frequently supplemented by human guidance. The effects of CR on cognitive, functional and clinical outcomes are consistently reported, yet the response is heterogeneous. In order to resolve this heterogeneity, we employed a multi-outcome meta-analytic approach, examined effects of CR on each outcome category separately and estimated directed effects between three outcome categories. We extracted treatment effects from 67 studies that trained patients with schizophrenia (total n = 4067) using either 1) computerized CR modality alone or 2) in combination with supplementary human guidance (SHG). All three outcome domains were significantly improved by CR with small to moderate effect sizes when assessing2019-01-01T00:00:00Z2019 Dec2026-05-30T15:14:56.497Z2025-04-19T22:38:12.004ZS-EPMC89425673155754810.1016/j.neubiorev.2019.09.031