biostudies-literatureZhang ZSpecial Funds for the Cultivation of Guangdong College Students’ Scientific and Technological Innovation6011632https://www.ebi.ac.uk/biostudies/studies/S-EPMC8942701biostudies-literatureUnknown2022<h4>Background</h4>Microbes have been shown to contribute to gastric cancer (GC), gastric bacteria and viruses are associated with gastric carcinogenesis. However, the relationship between gastric fungi and GC is still unclear. Our aim was to evaluate the gastric fungal microbiota in the GC microenvironment.<h4>Methods</h4>Gastric fungal microbiome profiling was performed with internal transcribed spacer (ITS) rDNA sequencing in primary tumor and corresponding paired normal mucosal tissues from 61 GC patients. Differences in microbial composition, taxa diversity, and predicted function were further analyzed.<h4>Results</h4>Dysbiosis of gastric mucosal fungal microbiome was observed between the tumor and normal groups in GC. The tumor group had a higher abundance of certain taxa than the noJournal of immunology researchDysbiosis of Gastric Mucosal Fungal Microbiota in the Gastric Cancer Microenvironment.PMC89427012020B1212010042021A1515011146pdjh2021b00972019JC05Y361Qiu YLiu HLi GDing WZhang ZFeng HXie QXu ZfalseDysbiosis of Gastric Mucosal Fungal Microbiota in the Gastric Cancer Microenvironment.<h4>Background</h4>Microbes have been shown to contribute to gastric cancer (GC), gastric bacteria and viruses are associated with gastric carcinogenesis. However, the relationship between gastric fungi and GC is still unclear. Our aim was to evaluate the gastric fungal microbiota in the GC microenvironment.<h4>Methods</h4>Gastric fungal microbiome profiling was performed with internal transcribed spacer (ITS) rDNA sequencing in primary tumor and corresponding paired normal mucosal tissues from 61 GC patients. Differences in microbial composition, taxa diversity, and predicted function were further analyzed.<h4>Results</h4>Dysbiosis of gastric mucosal fungal microbiome was observed between the tumor and normal groups in GC. The tumor group had a higher abundance of certain taxa than the no2022-01-01T00:00:00Z20222025-04-19T12:52:16.178Z2025-04-19T12:52:16.178ZS-EPMC89427013534058310.1155/2022/6011632