{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li S"],"funding":["the grants from the National Key R&D Program of China","Technology Bureau of Jiaxing, Zhejiang Province","Research Fund for Academician Lin He New Medicine","the Public Welfare Technology Research Program of Zhejiang Province","Health Development Planning Commission of Zhejiang Province"],"pagination":["488-497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943331"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["247(6)"],"pubmed_abstract":["Among different types of congenital heart diseases, ventricular septal defect is the most frequently diagnosed type and is frequently missed in early prenatal screening programs. Herein, we explored the role of maternal serum-derived exosomes in detecting and predicting ventricular septal defect in fetuses in the early stage of pregnancy. A total of 104 pregnant women consisting of 52 ventricular septal defect cases and 52 healthy controls were recruited. TMT/iTRAQ proteomic analysis uncovered 15 maternal serum exosomal proteins, which showed differential expression between ventricular septal defect and control groups. Among these, four down-regulated proteins, lactoferrin, SBSN, DCD, and MBD3, were validated by Western blot. The protein lactoferrin was additionally verified by ELISA which"],"journal":["Experimental biology and medicine (Maywood, N.J.)"],"pubmed_title":["Maternal serum-derived exosomal lactoferrin as a marker in detecting and predicting ventricular septal defect in fetuses."],"pmcid":["PMC8943331"],"funding_grant_id":["LGF19H040005 and LGF18H040008","2020AD10030","2018YFC1004900","2019KY221, 2021KY1120 and 2021KY357","19331201 and 19331202"],"pubmed_authors":["Liu X","Jin F","Li S","Zhou Q","Tang P","Dong J","Che X","Jin Y","Ni M","Chai X"],"additional_accession":[]},"is_claimable":false,"name":"Maternal serum-derived exosomal lactoferrin as a marker in detecting and predicting ventricular septal defect in fetuses.","description":"Among different types of congenital heart diseases, ventricular septal defect is the most frequently diagnosed type and is frequently missed in early prenatal screening programs. Herein, we explored the role of maternal serum-derived exosomes in detecting and predicting ventricular septal defect in fetuses in the early stage of pregnancy. A total of 104 pregnant women consisting of 52 ventricular septal defect cases and 52 healthy controls were recruited. TMT/iTRAQ proteomic analysis uncovered 15 maternal serum exosomal proteins, which showed differential expression between ventricular septal defect and control groups. Among these, four down-regulated proteins, lactoferrin, SBSN, DCD, and MBD3, were validated by Western blot. The protein lactoferrin was additionally verified by ELISA which","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-31T16:02:58.295Z","creation":"2025-02-19T01:27:58.655Z"},"accession":"S-EPMC8943331","cross_references":{"pubmed":["34871505"],"doi":["10.1177/15353702211060517"]}}