{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(1)"],"submitter":["Mpina M"],"pubmed_abstract":["<h4>Background</h4>Progress towards malaria elimination has stagnated, partly because infections persisting at low parasite densities comprise a large reservoir contributing to ongoing malaria transmission and are difficult to detect. This study compared the performance of an ultrasensitive rapid diagnostic test (uRDT) designed to detect low density infections to a conventional RDT (cRDT), expert microscopy using Giemsa-stained thick blood smears (TBS), and quantitative polymerase chain reaction (qPCR) during a controlled human malaria infection (CHMI) study conducted in malaria exposed adults (NCT03590340).<h4>Methods</h4>Blood samples were collected from healthy Equatoguineans aged 18-35 years beginning on day 8 after CHMI with 3.2 × 10<sup>3</sup> cryopreserved, infectious Plasmodium fa"],"journal":["Malaria journal"],"pagination":["99"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943516"],"repository":["biostudies-literature"],"pubmed_title":["Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea."],"pmcid":["PMC8943516"],"pubmed_authors":["Rivas MR","Chuquiyauri R","Hamad A","Abdulla S","Lopez MSA","Daubenberger CA","Nyakarungu E","Hoffman SL","Billingsley PF","Manguire B","Saverino E","Kim Lee Sim B","Garcia GA","Maas C","Falla CC","Mtoro A","Pasialo B","Momo JC","Deal A","Stabler TC","Eyang MAO","Schindler T","Raso J","Del Carmen Ovono Davis M","Acuche Pupu L","Jongo S","Tanner M","Preston Church LW","Urbano V","Richie TL","Mpina M"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea.","description":"<h4>Background</h4>Progress towards malaria elimination has stagnated, partly because infections persisting at low parasite densities comprise a large reservoir contributing to ongoing malaria transmission and are difficult to detect. This study compared the performance of an ultrasensitive rapid diagnostic test (uRDT) designed to detect low density infections to a conventional RDT (cRDT), expert microscopy using Giemsa-stained thick blood smears (TBS), and quantitative polymerase chain reaction (qPCR) during a controlled human malaria infection (CHMI) study conducted in malaria exposed adults (NCT03590340).<h4>Methods</h4>Blood samples were collected from healthy Equatoguineans aged 18-35 years beginning on day 8 after CHMI with 3.2 × 10<sup>3</sup> cryopreserved, infectious Plasmodium fa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-31T04:00:43.997Z","creation":"2025-04-04T19:30:47.814Z"},"accession":"S-EPMC8943516","cross_references":{"pubmed":["35331251"],"doi":["10.1186/s12936-022-04103-y"]}}