biostudies-literatureUnknown50(3)Kharel S<h4>Objective</h4>The mean platelet volume (MPV) is a measure of platelet size, and it is considered a surrogate marker of platelet activation. Because the correlation between platelet count/size and lung cancer prognosis remains unclear, this meta-analysis comprehensively evaluated the prognostic significance of MPV among patients with lung cancer.<h4>Methods</h4>A systematic search of PubMed, Embase, Google Scholar, and additional sources of relevant studies were conducted with no language restrictions from inception to 7 May 2021. Overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS), as well as their hazard ratios (HR) and 95% confidence intervals (CIs), were pooled to evaluate the relationship between MPV and survival. The study protocol was registered The Journal of international medical research3000605221084874https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943633biostudies-literaturePrognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis.PMC8943633Rawat RKharel SShilpakar RShakya PShrestha SfalsePrognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis.<h4>Objective</h4>The mean platelet volume (MPV) is a measure of platelet size, and it is considered a surrogate marker of platelet activation. Because the correlation between platelet count/size and lung cancer prognosis remains unclear, this meta-analysis comprehensively evaluated the prognostic significance of MPV among patients with lung cancer.<h4>Methods</h4>A systematic search of PubMed, Embase, Google Scholar, and additional sources of relevant studies were conducted with no language restrictions from inception to 7 May 2021. Overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS), as well as their hazard ratios (HR) and 95% confidence intervals (CIs), were pooled to evaluate the relationship between MPV and survival. The study protocol was registered 2022-01-01T00:00:00Z2022 Mar2025-04-21T23:14:57.077Z2025-04-05T19:05:16.403ZS-EPMC89436333531375610.1177/03000605221084874