{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kirkman DL"],"funding":["NHLBI NIH HHS","National Heart, Lung, and Blood Institute","NIGMS NIH HHS"],"pagination":["101469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943710"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(6)"],"pubmed_abstract":["<h4>Background</h4>Patients with chronic kidney disease have reduced cardiorespiratory fitness levels that contribute to mortality.<h4>Objectives</h4>The purpose of this study was to investigate the effects of aerobic exercise on cardiopulmonary function in patients with chronic kidney disease.<h4>Methods</h4>A total of 36 patients (mean [SD] estimated glomerular filtration rate 44 [12] ml/min/1.73m<sup>2</sup>) were randomly allocated to an exercise training or a control arm over 12 weeks. The exercise training group performed aerobic exercise for 45min 3 times/week at 65% to 80% heart rate reserve. The control group received routine care. Outcome measures were assessed at baseline and 12 weeks. Cardiopulmonary exercise testing was performed on a cycle ergometer with workload increased by"],"journal":["Annals of physical and rehabilitation medicine"],"pubmed_title":["A randomized trial of aerobic exercise in chronic kidney disease: Evidence for blunted cardiopulmonary adaptations."],"pmcid":["PMC8943710"],"funding_grant_id":["P20 GM113125","R01 HL113514"],"pubmed_authors":["Ramick MG","Townsend RR","Kirkman DL","Muth BJ","Edwards DG","Stock JM"],"additional_accession":[]},"is_claimable":false,"name":"A randomized trial of aerobic exercise in chronic kidney disease: Evidence for blunted cardiopulmonary adaptations.","description":"<h4>Background</h4>Patients with chronic kidney disease have reduced cardiorespiratory fitness levels that contribute to mortality.<h4>Objectives</h4>The purpose of this study was to investigate the effects of aerobic exercise on cardiopulmonary function in patients with chronic kidney disease.<h4>Methods</h4>A total of 36 patients (mean [SD] estimated glomerular filtration rate 44 [12] ml/min/1.73m<sup>2</sup>) were randomly allocated to an exercise training or a control arm over 12 weeks. The exercise training group performed aerobic exercise for 45min 3 times/week at 65% to 80% heart rate reserve. The control group received routine care. Outcome measures were assessed at baseline and 12 weeks. Cardiopulmonary exercise testing was performed on a cycle ergometer with workload increased by","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T22:33:57.841Z","creation":"2025-02-19T03:23:48.037Z"},"accession":"S-EPMC8943710","cross_references":{"pubmed":["33316435"],"doi":["10.1016/j.rehab.2020.101469"]}}