biostudies-literatureKirkman DLNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNIGMS NIH HHS101469https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943710biostudies-literatureUnknown64(6)<h4>Background</h4>Patients with chronic kidney disease have reduced cardiorespiratory fitness levels that contribute to mortality.<h4>Objectives</h4>The purpose of this study was to investigate the effects of aerobic exercise on cardiopulmonary function in patients with chronic kidney disease.<h4>Methods</h4>A total of 36 patients (mean [SD] estimated glomerular filtration rate 44 [12] ml/min/1.73m²) were randomly allocated to an exercise training or a control arm over 12 weeks. The exercise training group performed aerobic exercise for 45min 3 times/week at 65% to 80% heart rate reserve. The control group received routine care. Outcome measures were assessed at baseline and 12 weeks. Cardiopulmonary exercise testing was performed on a cycle ergometer with workload increased byAnnals of physical and rehabilitation medicineA randomized trial of aerobic exercise in chronic kidney disease: Evidence for blunted cardiopulmonary adaptations.PMC8943710P20 GM113125R01 HL113514Ramick MGTownsend RRKirkman DLMuth BJEdwards DGStock JMfalseA randomized trial of aerobic exercise in chronic kidney disease: Evidence for blunted cardiopulmonary adaptations.<h4>Background</h4>Patients with chronic kidney disease have reduced cardiorespiratory fitness levels that contribute to mortality.<h4>Objectives</h4>The purpose of this study was to investigate the effects of aerobic exercise on cardiopulmonary function in patients with chronic kidney disease.<h4>Methods</h4>A total of 36 patients (mean [SD] estimated glomerular filtration rate 44 [12] ml/min/1.73m²) were randomly allocated to an exercise training or a control arm over 12 weeks. The exercise training group performed aerobic exercise for 45min 3 times/week at 65% to 80% heart rate reserve. The control group received routine care. Outcome measures were assessed at baseline and 12 weeks. Cardiopulmonary exercise testing was performed on a cycle ergometer with workload increased by2021-01-01T00:00:00Z2021 Nov2025-04-04T22:33:57.841Z2025-02-19T03:23:48.037ZS-EPMC89437103331643510.1016/j.rehab.2020.101469