biostudies-literaturevan Meijel LAEuropean Foundation for the Study of Diabetese002401https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943734biostudies-literatureUnknown10(2)<h4>Introduction</h4>Impaired awareness of hypoglycemia, clinically reflected by the inability to timely detect hypoglycemia, affects approximately 25% of the people with type 1 diabetes. Both altered brain lactate handling and increased cerebral blood flow (CBF) during hypoglycemia appear to be involved in the pathogenesis of impaired awareness of hypoglycemia. Here we examine the effect of lactate on CBF during hypoglycemia.<h4>Research design and methods</h4>Nine people with type 1 diabetes and normal awareness of hypoglycemia underwent two hyperinsulinemic euglycemic-hypoglycemic (3.0 mmol/L) glucose clamps in a 3T MR system, once with sodium lactate infusion and once with sodium chloride infusion. Global and regional changes in CBF were determined using pseudocontinuous arterial spin BMJ open diabetes research & careEffect of lactate administration on cerebral blood flow during hypoglycemia in people with type 1 diabetes.PMC8943734No grant number applicableGrandjean Jde Galan BEvan Asten JJATack CJWiegers ECHeerschap Avan Meijel LAvan der Graaf MfalseEffect of lactate administration on cerebral blood flow during hypoglycemia in people with type 1 diabetes.<h4>Introduction</h4>Impaired awareness of hypoglycemia, clinically reflected by the inability to timely detect hypoglycemia, affects approximately 25% of the people with type 1 diabetes. Both altered brain lactate handling and increased cerebral blood flow (CBF) during hypoglycemia appear to be involved in the pathogenesis of impaired awareness of hypoglycemia. Here we examine the effect of lactate on CBF during hypoglycemia.<h4>Research design and methods</h4>Nine people with type 1 diabetes and normal awareness of hypoglycemia underwent two hyperinsulinemic euglycemic-hypoglycemic (3.0 mmol/L) glucose clamps in a 3T MR system, once with sodium lactate infusion and once with sodium chloride infusion. Global and regional changes in CBF were determined using pseudocontinuous arterial spin 2022-01-01T00:00:00Z2022 Mar2026-06-15T06:13:46.803Z2026-06-15T03:08:51.861ZS-EPMC89437343532188610.1136/bmjdrc-2021-002401