{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu WB"],"funding":["Fundamental Research Funds for the Central Universities","Ministry of Education of the People&apos;s Republic of China","Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","National Natural Science Foundation of China"],"pagination":["3519-3525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943849"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["A bifunctional silyl reagent Me<sub>2</sub>(CH<sub>2</sub>[double bond, length as m-dash]CH)SiCN has been developed as a novel ethylene equivalent for the Diels-Alder (DA) reaction. The use of this reagent enables the controllable synthesis of value-added cyclohexenyl ketones or 2-acyl cyclohexancarbonitrile derivatives through a five- or six-step tandem sequence based on a Wittig/cyanosilylation/DA reaction/<i>retro</i>-cyanosilylation/isomerization sequence that involves a temporary silicon-tethered intramolecular DA reaction."],"journal":["Chemical science"],"pubmed_title":["Me<sub>2</sub>(CH<sub>2</sub>[double bond, length as m-dash]CH)SiCN: a bifunctional ethylene equivalent for Diels-Alder reaction based controllable tandem synthesis."],"pmcid":["PMC8943849"],"funding_grant_id":["rdzh2020003","21N41900500","22171087","20JC1416900","21725203"],"pubmed_authors":["Wu WB","Yu JS","Mu BS","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Me<sub>2</sub>(CH<sub>2</sub>[double bond, length as m-dash]CH)SiCN: a bifunctional ethylene equivalent for Diels-Alder reaction based controllable tandem synthesis.","description":"A bifunctional silyl reagent Me<sub>2</sub>(CH<sub>2</sub>[double bond, length as m-dash]CH)SiCN has been developed as a novel ethylene equivalent for the Diels-Alder (DA) reaction. The use of this reagent enables the controllable synthesis of value-added cyclohexenyl ketones or 2-acyl cyclohexancarbonitrile derivatives through a five- or six-step tandem sequence based on a Wittig/cyanosilylation/DA reaction/<i>retro</i>-cyanosilylation/isomerization sequence that involves a temporary silicon-tethered intramolecular DA reaction.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T16:18:32.038Z","creation":"2025-04-19T16:18:32.038Z"},"accession":"S-EPMC8943849","cross_references":{"pubmed":["35432855"],"doi":["10.1039/d2sc00147k"]}}