biostudies-literatureGonzales MMNational Institute of Neurological Disorders and StrokeNIA NIH HHSNational Institute on Aginge12298https://www.ebi.ac.uk/biostudies/studies/S-EPMC8943903biostudies-literatureUnknown14(1)<b>Introduction</b>: The clinical translation of biofluid markers for dementia requires validation in diverse cohorts. The study goal was to evaluate if blood biomarkers reflecting diverse pathophysiological processes predict disease progression in Mexican American adults. <b>Methods</b>: Mexican American adults (n = 745), 50 years of age and older, completed annual assessments over a mean of 4 years. Serum collected at baseline was assayed for total tau, neurofilament light (NFL), ubiquitin carboxyl-terminal hydrolase LI, glial fibrillary acidic protein (GFAP), soluble cluster of differentiation 14 (sCD14), and chitinase-3-like protein 1 (YKL-40). <b>Results</b>: Higher GFAP and NFL were associated with global cognitive decline. Only GFAP was associated with increased incident dementia riAlzheimer's & dementia (Amsterdam, Netherlands)Blood biomarkers for cognitive decline and clinical progression in a Mexican American cohort.PMC8943903AG059421AG054076P30 AG059305NS100605DP1 AG069870P30 AG066546R01 AG066524AG066546Royall DRGonzalez DAZare HO'Bryant SParent DMWang CPSatizabal CLShort MISeshadri SMaestre GEKautz TGonzales MMTracy RPMacCarthy DfalseBlood biomarkers for cognitive decline and clinical progression in a Mexican American cohort.<b>Introduction</b>: The clinical translation of biofluid markers for dementia requires validation in diverse cohorts. The study goal was to evaluate if blood biomarkers reflecting diverse pathophysiological processes predict disease progression in Mexican American adults. <b>Methods</b>: Mexican American adults (n = 745), 50 years of age and older, completed annual assessments over a mean of 4 years. Serum collected at baseline was assayed for total tau, neurofilament light (NFL), ubiquitin carboxyl-terminal hydrolase LI, glial fibrillary acidic protein (GFAP), soluble cluster of differentiation 14 (sCD14), and chitinase-3-like protein 1 (YKL-40). <b>Results</b>: Higher GFAP and NFL were associated with global cognitive decline. Only GFAP was associated with increased incident dementia ri2022-01-01T00:00:00Z20222025-04-04T07:33:38.624Z2025-04-04T07:33:38.624ZS-EPMC89439033535648710.1002/dad2.12298