biostudies-literatureHilton CBritish Heart FoundationMedical Research Council and Novo Nordisk Uk Research FoundationMedical Research CouncilNational Institute for Health Research (NIHR)75-81https://www.ebi.ac.uk/biostudies/studies/S-EPMC8944227biostudies-literatureUnknown17(1)<h4>Background</h4>Body composition is associated with bone mineral density (BMD), but the precise associations between body fat distribution and BMD remain unclear. The regional adipose tissue depots have different metabolic profiles. We hypothesized that they would have independent associations with BMD.<h4>Research design and methods</h4>We used data from 4,900 healthy individuals aged 30-50 years old from the Oxford Biobank to analyze associations between regional fat mass, lean mass and total BMD.<h4>Results</h4>Total lean mass was strongly positively associated with BMD. An increase in total BMD was observed with increasing mass of all the fat depots, as measured either by anthropometry or DXA, when accounting for lean mass. However, on adjustment for both total fat mass and lean masExpert review of endocrinology & metabolismThe associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study.PMC8944227FS/16/45/32359RG/17/1/32663G1001959CL-2019-13-007Karpe FNeville MJVasan SKChristodoulides CHilton CfalseThe associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study.<h4>Background</h4>Body composition is associated with bone mineral density (BMD), but the precise associations between body fat distribution and BMD remain unclear. The regional adipose tissue depots have different metabolic profiles. We hypothesized that they would have independent associations with BMD.<h4>Research design and methods</h4>We used data from 4,900 healthy individuals aged 30-50 years old from the Oxford Biobank to analyze associations between regional fat mass, lean mass and total BMD.<h4>Results</h4>Total lean mass was strongly positively associated with BMD. An increase in total BMD was observed with increasing mass of all the fat depots, as measured either by anthropometry or DXA, when accounting for lean mass. However, on adjustment for both total fat mass and lean mas2022-01-01T00:00:00Z2022 Jan2025-04-19T09:23:59.075Z2025-04-19T09:23:59.075ZS-EPMC89442273485973910.1080/17446651.2022.2008238