{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Q"],"funding":["National Natural Science Foundation of China"],"pagination":["174-182"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8944309"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(2)"],"pubmed_abstract":["Radioresistance of prostate cancer (PCa) is a major factor leading to local failure of radiotherapy. STAT3 is an oncogenic protein that was recently found to be activated in PCa tumors. This study aimed to investigate the radiosensitization effect of targeting STAT3 in PCa tumors. Here, the radiosensitization effect of STAT3 blockade was investigated by clonogenic assay, flow cytometry and western blot analysis in human PCa cells in vitro and in vivo. We demonstrated that STAT3 blockade with a STAT3 inhibitor or siRNA increased the radiosensitivity of PCa cells and that radiation together with STAT3 blockade induced more apoptosis and double-strand breaks (DSBs) than radiation alone in LNCaP cells. In addition, radiation induced STAT3 activation and survivin expression in PCa cells, which "],"journal":["Journal of radiation research"],"pubmed_title":["STAT3 as a target for sensitizing prostate cancer cells to irradiation."],"pmcid":["PMC8944309"],"funding_grant_id":["81772499","81572287","81201795"],"pubmed_authors":["Liang G","Wei SZ","Deng KL","Luo Y","Zhou XM","Cui DS","Luo B","Zhang Q","Liang XJ"],"additional_accession":[]},"is_claimable":false,"name":"STAT3 as a target for sensitizing prostate cancer cells to irradiation.","description":"Radioresistance of prostate cancer (PCa) is a major factor leading to local failure of radiotherapy. STAT3 is an oncogenic protein that was recently found to be activated in PCa tumors. This study aimed to investigate the radiosensitization effect of targeting STAT3 in PCa tumors. Here, the radiosensitization effect of STAT3 blockade was investigated by clonogenic assay, flow cytometry and western blot analysis in human PCa cells in vitro and in vivo. We demonstrated that STAT3 blockade with a STAT3 inhibitor or siRNA increased the radiosensitivity of PCa cells and that radiation together with STAT3 blockade induced more apoptosis and double-strand breaks (DSBs) than radiation alone in LNCaP cells. In addition, radiation induced STAT3 activation and survivin expression in PCa cells, which ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T15:15:37.184Z","creation":"2025-04-06T14:51:12.333Z"},"accession":"S-EPMC8944309","cross_references":{"pubmed":["34970978"],"doi":["10.1093/jrr/rrab117"]}}