{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Wang D"],"pubmed_abstract":["In this study, we evaluated the roles of heat-induced circEZH2 in the regulation of milk fat metabolism. CircEZH2 overexpression increased HC11 cell proliferation and decreased apoptosis. These changes were accompanied by increased expression of proliferation marker proteins (PCNA, Cyclin D, and Cyclin E) and the anti-apoptotic protein Bcl2, while expression of the pro-apoptotic proteins Bax and cleaved-caspase was reduced. SiRNA-mediated silencing of EZH2 in HC11 cells had the opposite effects. CircEZH2 overexpression promoted the uptake of a fluorescent fatty acid (Bodipy) as well as expression of the fatty acid transport-related protein CD36, lipolysis-related protein LPL, and unsaturated fatty acid metabolism-related proteins FADS1 and SCD1. Dual luciferase reporter assays verified the"],"journal":["Animals : an open access journal from MDPI"],"pagination":["718"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8944462"],"repository":["biostudies-literature"],"pubmed_title":["CircEZH2 Regulates Milk Fat Metabolism through miR-378b Sponge Activity."],"pmcid":["PMC8944462"],"pubmed_authors":["Luo J","Zhang Y","Wang D","Xi Q","Zhao Z","Sun J","Shi Y","Chen T"],"additional_accession":[]},"is_claimable":false,"name":"CircEZH2 Regulates Milk Fat Metabolism through miR-378b Sponge Activity.","description":"In this study, we evaluated the roles of heat-induced circEZH2 in the regulation of milk fat metabolism. CircEZH2 overexpression increased HC11 cell proliferation and decreased apoptosis. These changes were accompanied by increased expression of proliferation marker proteins (PCNA, Cyclin D, and Cyclin E) and the anti-apoptotic protein Bcl2, while expression of the pro-apoptotic proteins Bax and cleaved-caspase was reduced. SiRNA-mediated silencing of EZH2 in HC11 cells had the opposite effects. CircEZH2 overexpression promoted the uptake of a fluorescent fatty acid (Bodipy) as well as expression of the fatty acid transport-related protein CD36, lipolysis-related protein LPL, and unsaturated fatty acid metabolism-related proteins FADS1 and SCD1. Dual luciferase reporter assays verified the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T23:17:09.245Z","creation":"2025-04-04T23:17:09.245Z"},"accession":"S-EPMC8944462","cross_references":{"pubmed":["35327115"],"doi":["10.3390/ani12060718"]}}