{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["Public Welfare Foundation of Ningbo City","Li Dak Sum Yip Yio Chin Kenneth Li  Marine Biopharmaceutical Development Fund","National Natural Science Foundation of China","Zhejiang Basic Public Welfare Research Project","Higher Education Discipline Innovation Project","Ningbo Key Science and Technology Development Program"],"pagination":["9909-9916"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8945076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(11)"],"pubmed_abstract":["Two rare tetracyclic skeleton alkaloids named perinadines B and C (<b>1</b> and <b>2</b>) were isolated as mixtures of epimers from the marine-derived <i>Aspergillus</i> sp. LS116 driven by molecular networking. The planar structures of <b>1</b> and <b>2</b> were characterized by comprehensive spectroscopic data. Additionally, compounds <b>1</b> and <b>2</b> showed moderate <i>in vitro</i> antibacterial activity against <i>Bacillus subtilis</i> with minimum inhibitory concentration values of 32 and 64 μg/mL, respectively. Besides, both of the compounds were evaluated for anti-inflammatory activities in an <i>in vivo</i> zebra fish model."],"journal":["ACS omega"],"pubmed_title":["Molecular Networking-Driven Discovery of Antibacterial Perinadines, New Tetracyclic Alkaloids from the Marine Sponge-Derived Fungus <i>Aspergillus</i> sp."],"pmcid":["PMC8945076"],"funding_grant_id":["2021Z046","42176101","41706167","42006104","LGF22B020002","D16013","2021S059"],"pubmed_authors":["Liu Y","He S","Wu B","Yan X","Ding L","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Networking-Driven Discovery of Antibacterial Perinadines, New Tetracyclic Alkaloids from the Marine Sponge-Derived Fungus <i>Aspergillus</i> sp.","description":"Two rare tetracyclic skeleton alkaloids named perinadines B and C (<b>1</b> and <b>2</b>) were isolated as mixtures of epimers from the marine-derived <i>Aspergillus</i> sp. LS116 driven by molecular networking. The planar structures of <b>1</b> and <b>2</b> were characterized by comprehensive spectroscopic data. Additionally, compounds <b>1</b> and <b>2</b> showed moderate <i>in vitro</i> antibacterial activity against <i>Bacillus subtilis</i> with minimum inhibitory concentration values of 32 and 64 μg/mL, respectively. Besides, both of the compounds were evaluated for anti-inflammatory activities in an <i>in vivo</i> zebra fish model.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-30T15:02:52.581Z","creation":"2025-04-04T23:04:39.529Z"},"accession":"S-EPMC8945076","cross_references":{"pubmed":["35350304"],"doi":["10.1021/acsomega.2c00402"]}}