{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Franko A"],"funding":["German Center for Diabetes Research"],"pagination":["616"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8945094"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(3)"],"pubmed_abstract":["Glucotoxic metabolites and pathways play a crucial role in diabetic complications, and new treatment options which improve glucotoxicity are highly warranted. In this study, we analyzed bezafibrate (BEZ) treated, streptozotocin (STZ) injected mice, which showed an improved glucose metabolism compared to untreated STZ animals. In order to identify key molecules and pathways which participate in the beneficial effects of BEZ, we studied plasma, skeletal muscle, white adipose tissue (WAT) and liver samples using non-targeted metabolomics (NMR spectroscopy), targeted metabolomics (mass spectrometry), microarrays and mitochondrial enzyme activity measurements, with a particular focus on the liver. The analysis of muscle and WAT demonstrated that STZ treatment elevated inflammatory pathways and "],"journal":["Biomedicines"],"pubmed_title":["Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice."],"pmcid":["PMC8945094"],"funding_grant_id":["(e.V.)"],"pubmed_authors":["Wiesner R","Franko A","Heinzmann SS","von Kleist-Retzow JC","Haring HU","Birkenfeld AL","de Angelis MH","Adamski J","Prehn C","Beckers J","Heni M","Schmitt-Kopplin P","Irmler M"],"additional_accession":[]},"is_claimable":false,"name":"Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice.","description":"Glucotoxic metabolites and pathways play a crucial role in diabetic complications, and new treatment options which improve glucotoxicity are highly warranted. In this study, we analyzed bezafibrate (BEZ) treated, streptozotocin (STZ) injected mice, which showed an improved glucose metabolism compared to untreated STZ animals. In order to identify key molecules and pathways which participate in the beneficial effects of BEZ, we studied plasma, skeletal muscle, white adipose tissue (WAT) and liver samples using non-targeted metabolomics (NMR spectroscopy), targeted metabolomics (mass spectrometry), microarrays and mitochondrial enzyme activity measurements, with a particular focus on the liver. The analysis of muscle and WAT demonstrated that STZ treatment elevated inflammatory pathways and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T08:24:22.577Z","creation":"2025-04-04T08:24:22.577Z"},"accession":"S-EPMC8945094","cross_references":{"pubmed":["35327418"],"doi":["10.3390/biomedicines10030616"]}}