biostudies-literatureLi JNIBIB NIH HHSNICHD NIH HHSNIA NIH HHSNCRR NIH HHSNIMH NIH HHSNINDS NIH HHSNIGMS NIH HHS118758https://www.ebi.ac.uk/biostudies/studies/S-EPMC8945548biostudies-literatureUnknown245The default mode network (DMN) mediates self-awareness and introspection, core components of human consciousness. Therapies to restore consciousness in patients with severe brain injuries have historically targeted subcortical sites in the brainstem, thalamus, hypothalamus, basal forebrain, and basal ganglia, with the goal of reactivating cortical DMN nodes. However, the subcortical connectivity of the DMN has not been fully mapped, and optimal subcortical targets for therapeutic neuromodulation of consciousness have not been identified. In this work, we created a comprehensive map of DMN subcortical connectivity by combining high-resolution functional and structural datasets with advanced signal processing methods. We analyzed 7 Tesla resting-state functional MRI (rs-fMRI) data from 168 hNeuroImageMapping the subcortical connectivity of the human default mode network.PMC8945548S10 RR023401U01 MH117023RF1 MH123195P41 EB015896R01 NS083534U01 MH093765U01 NS086625R01 AG016495U24 NS100591R01 NS070963R01 GM121885R01 EB023281S10 RR019307DP2 HD101400S10 RR023043R01 AG008122RF1 MH121885R21 EB018907R01 NS052585R21 NS072652R01 EB019956RF1 NS115268R01 NS105820R56 AG064027P41 EB030006R01 EB006758R21 NS109627R01 AG064027Li JDougherty DDFischl BCurley WHHorn AEdlow BLGuerin BDalca AVfalseMapping the subcortical connectivity of the human default mode network.The default mode network (DMN) mediates self-awareness and introspection, core components of human consciousness. Therapies to restore consciousness in patients with severe brain injuries have historically targeted subcortical sites in the brainstem, thalamus, hypothalamus, basal forebrain, and basal ganglia, with the goal of reactivating cortical DMN nodes. However, the subcortical connectivity of the DMN has not been fully mapped, and optimal subcortical targets for therapeutic neuromodulation of consciousness have not been identified. In this work, we created a comprehensive map of DMN subcortical connectivity by combining high-resolution functional and structural datasets with advanced signal processing methods. We analyzed 7 Tesla resting-state functional MRI (rs-fMRI) data from 168 h2021-01-01T00:00:00Z2021 Dec2025-04-21T23:19:04.694Z2025-04-05T19:06:03.157ZS-EPMC89455483483894910.1016/j.neuroimage.2021.118758