{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(20)"],"submitter":["Weiss A"],"funding":["CIHR"],"pubmed_abstract":["Bone marrow (BM) is the primary site of hematopoiesis and is responsible for a lifelong supply of all blood cell lineages. The process of hematopoiesis follows key intrinsic programs that also integrate instructive signals from the BM niche. First identified as an erythropoietin-potentiating factor, the tissue inhibitor of metalloproteinase (TIMP) protein family has expanded to 4 members and has widely come to be viewed as a classical regulator of tissue homeostasis. By virtue of metalloprotease inhibition, TIMPs not only regulate extracellular matrix turnover but also control growth factor bioavailability. The 4 mammalian TIMPs possess overlapping enzyme-inhibition profiles and have never been studied for their cumulative role in hematopoiesis. Here, we show that TIMPs are critical for po"],"journal":["Blood advances"],"pagination":["3960-3974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8945646"],"repository":["biostudies-literature"],"pubmed_title":["Abnormal B-cell development in TIMP-deficient bone marrow."],"pmcid":["PMC8945646"],"pubmed_authors":["Narala S","Fang H","Saw S","Shetty R","Aiken A","Weiss A","Waterhouse PD","Khokha R","Shao YW","Aliar K"],"additional_accession":[]},"is_claimable":false,"name":"Abnormal B-cell development in TIMP-deficient bone marrow.","description":"Bone marrow (BM) is the primary site of hematopoiesis and is responsible for a lifelong supply of all blood cell lineages. The process of hematopoiesis follows key intrinsic programs that also integrate instructive signals from the BM niche. First identified as an erythropoietin-potentiating factor, the tissue inhibitor of metalloproteinase (TIMP) protein family has expanded to 4 members and has widely come to be viewed as a classical regulator of tissue homeostasis. By virtue of metalloprotease inhibition, TIMPs not only regulate extracellular matrix turnover but also control growth factor bioavailability. The 4 mammalian TIMPs possess overlapping enzyme-inhibition profiles and have never been studied for their cumulative role in hematopoiesis. Here, we show that TIMPs are critical for po","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-03-27T16:43:13.243Z","creation":"2025-04-07T11:41:39.694Z"},"accession":"S-EPMC8945646","cross_references":{"pubmed":["34500457"],"doi":["10.1182/bloodadvances.2020004101"]}}