{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sung JY"],"funding":["Korea Health Industry Development Institute"],"pagination":["1438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8945874"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(6)"],"pubmed_abstract":["The extracellular matrix (ECM) is an important regulator of all cellular functions, and the matrisome represents a major component of the tumor microenvironment. The matrisome is an essential component comprising genes encoding ECM glycoproteins, collagens, and proteoglycans; however, its role in cancer progression and the development of stem-like molecular subtypes in gastric cancer is unknown. We analyzed gastric cancer data from five molecular subtypes (<i>n</i> = 497) and found that metabolic reprograming differs based on the state of the matrisome. Approximately 95% of stem-like cancer type samples of gastric cancer were in the high-matrisome category, and energy metabolism was considerably increased in the high-matrisome group. Particularly, high glycosaminoglycan biosynthesis-chondr"],"journal":["Cancers"],"pubmed_title":["The Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer."],"pmcid":["PMC8945874"],"funding_grant_id":["HI14C1324"],"pubmed_authors":["Cheong JH","Sung JY"],"additional_accession":[]},"is_claimable":false,"name":"The Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer.","description":"The extracellular matrix (ECM) is an important regulator of all cellular functions, and the matrisome represents a major component of the tumor microenvironment. The matrisome is an essential component comprising genes encoding ECM glycoproteins, collagens, and proteoglycans; however, its role in cancer progression and the development of stem-like molecular subtypes in gastric cancer is unknown. We analyzed gastric cancer data from five molecular subtypes (<i>n</i> = 497) and found that metabolic reprograming differs based on the state of the matrisome. Approximately 95% of stem-like cancer type samples of gastric cancer were in the high-matrisome category, and energy metabolism was considerably increased in the high-matrisome group. Particularly, high glycosaminoglycan biosynthesis-chondr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-04-08T17:30:46.595Z","creation":"2026-04-08T07:42:41.878Z"},"accession":"S-EPMC8945874","cross_references":{"pubmed":["35326589"],"doi":["10.3390/cancers14061438"]}}