biostudies-literatureSung JYKorea Health Industry Development Institute1438https://www.ebi.ac.uk/biostudies/studies/S-EPMC8945874biostudies-literatureUnknown14(6)The extracellular matrix (ECM) is an important regulator of all cellular functions, and the matrisome represents a major component of the tumor microenvironment. The matrisome is an essential component comprising genes encoding ECM glycoproteins, collagens, and proteoglycans; however, its role in cancer progression and the development of stem-like molecular subtypes in gastric cancer is unknown. We analyzed gastric cancer data from five molecular subtypes (<i>n</i> = 497) and found that metabolic reprograming differs based on the state of the matrisome. Approximately 95% of stem-like cancer type samples of gastric cancer were in the high-matrisome category, and energy metabolism was considerably increased in the high-matrisome group. Particularly, high glycosaminoglycan biosynthesis-chondrCancersThe Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer.PMC8945874HI14C1324Cheong JHSung JYfalseThe Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer.The extracellular matrix (ECM) is an important regulator of all cellular functions, and the matrisome represents a major component of the tumor microenvironment. The matrisome is an essential component comprising genes encoding ECM glycoproteins, collagens, and proteoglycans; however, its role in cancer progression and the development of stem-like molecular subtypes in gastric cancer is unknown. We analyzed gastric cancer data from five molecular subtypes (<i>n</i> = 497) and found that metabolic reprograming differs based on the state of the matrisome. Approximately 95% of stem-like cancer type samples of gastric cancer were in the high-matrisome category, and energy metabolism was considerably increased in the high-matrisome group. Particularly, high glycosaminoglycan biosynthesis-chondr2022-01-01T00:00:00Z2022 Mar2026-04-08T17:30:46.595Z2026-04-08T07:42:41.878ZS-EPMC89458743532658910.3390/cancers14061438