{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(6)"],"submitter":["Burkard T"],"pubmed_abstract":["Hepatitis C virus (HCV) constitutes a global health problem, while hepatitis E virus (HEV) is the major cause of acute viral hepatitis globally. HCV/HEV co-infections have been poorly characterized, as they are hampered by the lack of robust HEV cell culture systems. This study developed experimental models to study HCV/HEV co-infections and investigate viral interference in cells and humanized mice. We used state-of-the art human hepatocytes tissue culture models to assess HEV and HCV replication in co- or super-transfection settings. Findings were confirmed by co- and super-infection experiments in human hepatocytes and in vivo in human liver chimeric mice. HEV was inhibited by concurrent HCV replication in human hepatocytes. This exclusion phenotype was linked to the protease activity o"],"journal":["Cells"],"pagination":["927"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8946046"],"repository":["biostudies-literature"],"pubmed_title":["Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems."],"pmcid":["PMC8946046"],"pubmed_authors":["Steinmann E","Friesland M","Verhoye L","Collignon L","Burkard T","Todt D","Sayed IM","Behrendt P","Nocke MK","Knegendorf L","Resner K","Wedemeyer H","Proske N","Bruggemann Y","Meuleman P"],"additional_accession":[]},"is_claimable":false,"name":"Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems.","description":"Hepatitis C virus (HCV) constitutes a global health problem, while hepatitis E virus (HEV) is the major cause of acute viral hepatitis globally. HCV/HEV co-infections have been poorly characterized, as they are hampered by the lack of robust HEV cell culture systems. This study developed experimental models to study HCV/HEV co-infections and investigate viral interference in cells and humanized mice. We used state-of-the art human hepatocytes tissue culture models to assess HEV and HCV replication in co- or super-transfection settings. Findings were confirmed by co- and super-infection experiments in human hepatocytes and in vivo in human liver chimeric mice. HEV was inhibited by concurrent HCV replication in human hepatocytes. This exclusion phenotype was linked to the protease activity o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T23:34:22.229Z","creation":"2025-04-04T23:34:22.229Z"},"accession":"S-EPMC8946046","cross_references":{"pubmed":["35326378"],"doi":["10.3390/cells11060927"]}}