biostudies-literatureUnknown9(4)Holger DJWe report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant <i>Acinetobacter baumannii</i> necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.Open forum infectious diseasesofac092https://www.ebi.ac.uk/biostudies/studies/S-EPMC8946682biostudies-literatureNovel Combination Therapy for Extensively Drug-Resistant <i>Acinetobacter baumannii</i> Necrotizing Pneumonia Complicated by Empyema: A Case Report.PMC8946682Kunz Coyne AJZhao JJSalimnia HSandhu ARybak MJHolger DJfalseNovel Combination Therapy for Extensively Drug-Resistant <i>Acinetobacter baumannii</i> Necrotizing Pneumonia Complicated by Empyema: A Case Report.We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant <i>Acinetobacter baumannii</i> necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.2022-01-01T00:00:00Z2022 Apr2026-05-31T21:02:36.341Z2025-04-04T21:43:17.672ZS-EPMC89466823535017410.1093/ofid/ofac092