biostudies-literatureSaatmann NGerman Research FoundationGerman Center for Diabetes ResearchGerman Federal Ministry of HealthSchmutzler StiftungEuropean Funds for Regional DevelopmentEUREKA Eurostars-2Ministry of Culture and Science of the state of North Rhine-WestphaliaGerman Federal Ministry of Education and Research1127-1139https://www.ebi.ac.uk/biostudies/studies/S-EPMC8947222biostudies-literatureUnknown107(4)<h4>Context</h4>Physical inactivity promotes insulin resistance and increases the risk of diabetes and cardiovascular disease. Recently introduced clustering based on simple clinical measures identified diabetes subgroups (clusters) with different risks of diabetes-related comorbidities and complications.<h4>Objective</h4>This study aims to determine differences in physical fitness and cardiovascular risk between diabetes subgroups and a glucose-tolerant control group (CON). We hypothesized that the severe insulin-resistant diabetes (SIRD) subgroup would be associated with lower physical fitness and increased cardiovascular risk.<h4>Methods</h4>The physical fitness and cardiovascular risk of 746 participants with recent-onset diabetes (diabetes duration of < 12 months, aged 18-69 years) anThe Journal of clinical endocrinology and metabolismPhysical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups.PMC8947222RTG/GRK 2576EFRE-0400191CRC1116-B09E!-113230-DIA-PEPNos. CRC/SFB 1116/2 B12CRC1116-B12Zaharia OPRoden MKelm MStrassburger KPesta DHSzendroedi JBurkart VSaatmann NGerdes NfalsePhysical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups.<h4>Context</h4>Physical inactivity promotes insulin resistance and increases the risk of diabetes and cardiovascular disease. Recently introduced clustering based on simple clinical measures identified diabetes subgroups (clusters) with different risks of diabetes-related comorbidities and complications.<h4>Objective</h4>This study aims to determine differences in physical fitness and cardiovascular risk between diabetes subgroups and a glucose-tolerant control group (CON). We hypothesized that the severe insulin-resistant diabetes (SIRD) subgroup would be associated with lower physical fitness and increased cardiovascular risk.<h4>Methods</h4>The physical fitness and cardiovascular risk of 746 participants with recent-onset diabetes (diabetes duration of < 12 months, aged 18-69 years) an2022-01-01T00:00:00Z2022 Mar2025-04-04T13:27:33.097Z2025-04-04T13:27:33.097ZS-EPMC89472223474863410.1210/clinem/dgab810