biostudies-literatureScully KJNational Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSNational Institutes of HealthCystic Fibrosis Foundation Clinical Research Awarde1444-e1454https://www.ebi.ac.uk/biostudies/studies/S-EPMC8947309biostudies-literatureUnknown107(4)<h4>Context</h4>The clinical utility and implications of continuous glucose monitoring (CGM) in cystic fibrosis (CF) are unclear.<h4>Objective</h4>We examined the correlation between CGM measures and clinical outcomes in adults with CF, investigated the relationship between hemoglobin A1c (HbA1c) and CGM-derived average glucose (AG), and explored CGM measures that distinguish cystic fibrosis-related diabetes (CFRD) from normal and abnormal glucose tolerance.<h4>Methods</h4>This prospective observational study included 77 adults with CF who had CGM and HbA1c measured at 2 to 3 time points 3 months apart.<h4>Results</h4>Thirty-one of the 77 participants met American Diabetes Association-recommended diagnostic criteria for CFRD by oral glucose tolerance testing and/or HbA1c. In all participanThe Journal of clinical endocrinology and metabolismContinuous Glucose Monitoring and HbA1c in Cystic Fibrosis: Clinical Correlations and Implications for CFRD Diagnosis.PMC8947309PUTMAN16A0T32 DK0076995T32DK007699Sherwood JSWexler DJRuazol MSawicki GSUluer AMarchetti PLarkin MZheng HPutman MSMartin KYonker LMSicilian LNeuringer IScully KJfalseContinuous Glucose Monitoring and HbA1c in Cystic Fibrosis: Clinical Correlations and Implications for CFRD Diagnosis.<h4>Context</h4>The clinical utility and implications of continuous glucose monitoring (CGM) in cystic fibrosis (CF) are unclear.<h4>Objective</h4>We examined the correlation between CGM measures and clinical outcomes in adults with CF, investigated the relationship between hemoglobin A1c (HbA1c) and CGM-derived average glucose (AG), and explored CGM measures that distinguish cystic fibrosis-related diabetes (CFRD) from normal and abnormal glucose tolerance.<h4>Methods</h4>This prospective observational study included 77 adults with CF who had CGM and HbA1c measured at 2 to 3 time points 3 months apart.<h4>Results</h4>Thirty-one of the 77 participants met American Diabetes Association-recommended diagnostic criteria for CFRD by oral glucose tolerance testing and/or HbA1c. In all participan2022-01-01T00:00:00Z2022 Mar2025-04-19T22:47:01.61Z2025-04-19T22:47:01.61ZS-EPMC89473093485000610.1210/clinem/dgab857