{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Chang C"],"pubmed_abstract":["<i>Background</i>/<i>Aim</i>. MircoRNA-4731-5p (miR-4731-5p) is a new miRNA involved in different human cancers, but its function has not been clarified in non-small-cell lung cancer (NSCLC). The present study attended to resolve the role of miR-4731-5p in NSCLC. <i>Materials and Methods</i>. The expression level of miR-4731-5p or ribosomal protein large P0 (RPLP0) and NSCLC clinicopathologic characteristics were analyzed. The binding between miR-4731-5p and RPLP0 was confirmed by TargetScan prediction and luciferase reporter experiment. Also, the probable role of miR-4731-5p in NSCLC via RPLP0 was elaborated by the MTT, western blotting, immunofluorescence, transwell, flow cytometry, and TUNEL assays. Moreover, <i>in vivo</i> verification was conducted in xenografted nude mice. <i>Results"],"journal":["Journal of oncology"],"pagination":["3793318"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8947863"],"repository":["biostudies-literature"],"pubmed_title":["miR-4731-5p Enhances Apoptosis and Alleviates Epithelial-Mesenchymal Transition through Targeting RPLP0 in Non-Small-Cell Lung Cancer."],"pmcid":["PMC8947863"],"pubmed_authors":["Xu M","Chang C"],"additional_accession":[]},"is_claimable":false,"name":"miR-4731-5p Enhances Apoptosis and Alleviates Epithelial-Mesenchymal Transition through Targeting RPLP0 in Non-Small-Cell Lung Cancer.","description":"<i>Background</i>/<i>Aim</i>. MircoRNA-4731-5p (miR-4731-5p) is a new miRNA involved in different human cancers, but its function has not been clarified in non-small-cell lung cancer (NSCLC). The present study attended to resolve the role of miR-4731-5p in NSCLC. <i>Materials and Methods</i>. The expression level of miR-4731-5p or ribosomal protein large P0 (RPLP0) and NSCLC clinicopathologic characteristics were analyzed. The binding between miR-4731-5p and RPLP0 was confirmed by TargetScan prediction and luciferase reporter experiment. Also, the probable role of miR-4731-5p in NSCLC via RPLP0 was elaborated by the MTT, western blotting, immunofluorescence, transwell, flow cytometry, and TUNEL assays. Moreover, <i>in vivo</i> verification was conducted in xenografted nude mice. <i>Results","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T09:23:14.396Z","creation":"2025-04-19T09:23:14.396Z"},"accession":"S-EPMC8947863","cross_references":{"pubmed":["35342398"],"doi":["10.1155/2022/3793318"]}}