{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Lyu T"],"pubmed_abstract":["<h4>Methods</h4>The CVA guinea pig model was successfully established by use of ovalbumin (OVA) sensitization and cigarette smoke (CS) exposure. The guinea pigs were divided into 6 groups: a control group, an OVA model group, an OVA + CS model group, a <i>Suhuang</i> treatment group, a BUD treatment group, and a combination (<i>Suhuang</i> and BUD) treatment group. The effects of the treatment were determined by measuring lung function (RI/Cydn) and cough symptoms (coughs number/cough latency) as outcome criteria. The levels of inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were determined by ELISA. Lung tissues were stained by hematoxylin and eosin (H&E). The expressions of GR/total p38 MAPK/p-p38 MAPK were detected by Western blot. The MKP-1 mRNA levels were detected by RT"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pagination":["1699429"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8947934"],"repository":["biostudies-literature"],"pubmed_title":["<i>Suhuang</i> Antitussive Capsule Ameliorates Corticosteroid Insensitivity in Cough Variant Asthma Guinea Pigs by Inhibiting p38 MAPK Signal Pathway."],"pmcid":["PMC8947934"],"pubmed_authors":["Li D","Zhang H","Lyu T","Chen S","Yang D"],"additional_accession":[]},"is_claimable":false,"name":"<i>Suhuang</i> Antitussive Capsule Ameliorates Corticosteroid Insensitivity in Cough Variant Asthma Guinea Pigs by Inhibiting p38 MAPK Signal Pathway.","description":"<h4>Methods</h4>The CVA guinea pig model was successfully established by use of ovalbumin (OVA) sensitization and cigarette smoke (CS) exposure. The guinea pigs were divided into 6 groups: a control group, an OVA model group, an OVA + CS model group, a <i>Suhuang</i> treatment group, a BUD treatment group, and a combination (<i>Suhuang</i> and BUD) treatment group. The effects of the treatment were determined by measuring lung function (RI/Cydn) and cough symptoms (coughs number/cough latency) as outcome criteria. The levels of inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were determined by ELISA. Lung tissues were stained by hematoxylin and eosin (H&E). The expressions of GR/total p38 MAPK/p-p38 MAPK were detected by Western blot. The MKP-1 mRNA levels were detected by RT","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T08:53:10.101Z","creation":"2025-04-04T08:53:10.101Z"},"accession":"S-EPMC8947934","cross_references":{"pubmed":["35341157"],"doi":["10.1155/2022/1699429"]}}