biostudies-literatureUnknown2022Lyu T<h4>Methods</h4>The CVA guinea pig model was successfully established by use of ovalbumin (OVA) sensitization and cigarette smoke (CS) exposure. The guinea pigs were divided into 6 groups: a control group, an OVA model group, an OVA + CS model group, a <i>Suhuang</i> treatment group, a BUD treatment group, and a combination (<i>Suhuang</i> and BUD) treatment group. The effects of the treatment were determined by measuring lung function (RI/Cydn) and cough symptoms (coughs number/cough latency) as outcome criteria. The levels of inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were determined by ELISA. Lung tissues were stained by hematoxylin and eosin (H&E). The expressions of GR/total p38 MAPK/p-p38 MAPK were detected by Western blot. The MKP-1 mRNA levels were detected by RTEvidence-based complementary and alternative medicine : eCAM1699429https://www.ebi.ac.uk/biostudies/studies/S-EPMC8947934biostudies-literature<i>Suhuang</i> Antitussive Capsule Ameliorates Corticosteroid Insensitivity in Cough Variant Asthma Guinea Pigs by Inhibiting p38 MAPK Signal Pathway.PMC8947934Li DZhang HLyu TChen SYang Dfalse<i>Suhuang</i> Antitussive Capsule Ameliorates Corticosteroid Insensitivity in Cough Variant Asthma Guinea Pigs by Inhibiting p38 MAPK Signal Pathway.<h4>Methods</h4>The CVA guinea pig model was successfully established by use of ovalbumin (OVA) sensitization and cigarette smoke (CS) exposure. The guinea pigs were divided into 6 groups: a control group, an OVA model group, an OVA + CS model group, a <i>Suhuang</i> treatment group, a BUD treatment group, and a combination (<i>Suhuang</i> and BUD) treatment group. The effects of the treatment were determined by measuring lung function (RI/Cydn) and cough symptoms (coughs number/cough latency) as outcome criteria. The levels of inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were determined by ELISA. Lung tissues were stained by hematoxylin and eosin (H&E). The expressions of GR/total p38 MAPK/p-p38 MAPK were detected by Western blot. The MKP-1 mRNA levels were detected by RT2022-01-01T00:00:00Z20222025-04-04T08:53:10.101Z2025-04-04T08:53:10.101ZS-EPMC89479343534115710.1155/2022/1699429