{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Warnecke T"],"pubmed_abstract":["Growing evidence suggests an increasing significance for the extent of gastrointestinal tract (GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms, including dysphagia, sialorrhea, bloating, nausea, vomiting, gastroparesis, and constipation during the disease course. The underlying pathomechanisms of this α-synucleinopathy play an important role in disease development and progression, i.e., early accumulation of Lewy pathology in the enteric and central nervous systems is implicated in pharyngeal discoordination, esophageal and gastric motility/peristalsis impairment, chronic pain, altered intestinal permeability and autonomic dysfunction of the colon, with subsequent constipation. Severe complications, including malnutrition, dehydration, insufficient drug"],"journal":["NPJ Parkinson's disease"],"pagination":["31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8948218"],"repository":["biostudies-literature"],"pubmed_title":["Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management."],"pmcid":["PMC8948218"],"pubmed_authors":["Del Tredici K","Claus I","Warnecke T","Jost WH","Schafer KH"],"additional_accession":[]},"is_claimable":false,"name":"Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management.","description":"Growing evidence suggests an increasing significance for the extent of gastrointestinal tract (GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms, including dysphagia, sialorrhea, bloating, nausea, vomiting, gastroparesis, and constipation during the disease course. The underlying pathomechanisms of this α-synucleinopathy play an important role in disease development and progression, i.e., early accumulation of Lewy pathology in the enteric and central nervous systems is implicated in pharyngeal discoordination, esophageal and gastric motility/peristalsis impairment, chronic pain, altered intestinal permeability and autonomic dysfunction of the colon, with subsequent constipation. Severe complications, including malnutrition, dehydration, insufficient drug","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-05-18T12:06:28.935Z","creation":"2025-05-18T12:06:28.935Z"},"accession":"S-EPMC8948218","cross_references":{"pubmed":["35332158"],"doi":["10.1038/s41531-022-00295-x"]}}